PMID: 11900299Mar 20, 2002Paper

Calmodulin and the philosopher's stone: Changing Ca2+ into arrhythmias

Journal of Cardiovascular Electrophysiology
Mark E Anderson

Abstract

Calmodulin and the Philosopher's Stone. It has been recognized for some time that intracellular Ca2+ ([Ca2+]i) can contribute to the genesis of cardiac arrhythmias, but understanding of the molecular signaling machinery that links disordered [Ca2+]i to arrhythmias has been lacking. Exciting recent work has focused on the ubiquitous intracellular Ca2+-binding protein calmodulin. Calmodulin is a molecular sensor that can translate increases in [Ca2+]i into modulatory signals for ion channels and activate other Ca2+-dependent signaling molecules. This article will examine the implications of these recent findings for arrhythmogenesis and the development of new antiarrhythmic therapies.

Citations

Nov 23, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chad E GrueterMark E Anderson
Dec 7, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Guoan ZhaoXiaoqing Quan
Jul 25, 2003·Pacing and Clinical Electrophysiology : PACE·Douglas P Zipes
Dec 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Badr A AlseikhanDavid T Yue
Dec 13, 2005·Journal of Internal Medicine·M E Anderson
Sep 23, 2008·Journal of Molecular and Cellular Cardiology·Sophie CardinStanley Nattel
Feb 4, 2006·Circulation Research·Sheldon E Litwin
Feb 7, 2003·Nature·Stanley Nattel
Aug 2, 2003·Journal of Cardiovascular Electrophysiology·Douglas P Zipes
Aug 2, 2003·Critical Reviews in Clinical Laboratory Sciences·William T Clusin
May 5, 2004·Médecine sciences : M/S·Marc Pourrier, Stanley Nattel
Apr 28, 2004·Cell Calcium·Gerhard Meissner
Nov 10, 2011·Biophysical Journal·Tao GuoDonald M Bers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Related Papers

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Cuntai ZhangZaiying Lu
Nature Reviews. Cardiology
Kurt C Roberts-ThomsonPrashanthan Sanders
© 2022 Meta ULC. All rights reserved