PMID: 6112944Jan 1, 1980Paper

Calmodulin and the plasma membrane calcium pump

Annals of the New York Academy of Sciences
F F VincenziB U Raess

Abstract

The data summarized and presented in this paper are consistent with the interpretation that CaM participates in the regulation of the plasma membrane calcium pump. Certain drugs, such as phenothiazines can antagonize CaM. Ca2+ loading of RBCs promotes CaM binding to RBC membranes and results in decreased responsiveness of the [Ca2+ + Mg2+)-ATPase to CaM. The latter effect may be mediated by a Ca2+ activated transglutaminase. Activation of (Ca2+ + Mg2+)-ATPase by CaM in vitro was shown not to be instantaneous, probably because of slow binding. CaM binding to isolated RBC membranes exhibits a Ca2+ dependence that is similar to that for activation of the (Ca2+ + Mg2+)-ATPase, and CaM binding does not decrease at high [Ca2+]s. Calculations based on assumed values for RBC [Ca2+], [CaM], and binding affinities of Ca2+ for CaM and CaM(Ca2+)n for the Ca2+ pump ATPase resulted in the tentative conclusion that most pump sites are occupied by CaM in the RBC in vivo. This conclusion, and the relatively slow time course of the CaM effect on (Ca2+ + Mg2+)-ATPase prompt us to suggest that, for all practical purposes, CaM is a subunit of the Ca2+ pump ATPase in vivo.

References

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Citations

Apr 29, 1992·Biochimica Et Biophysica Acta·L WuF F Vincenzi
Jan 1, 1985·Comparative Biochemistry and Physiology. A, Comparative Physiology·S J Publicover
Jan 1, 1985·Progress in Neurobiology·G Audesirk
Jan 1, 1985·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C O BewajiE A Bababunmi
Oct 1, 1994·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M Kurata, M Suzuki
Oct 1, 1993·Journal of Pharmacological and Toxicological Methods·S M SadrzadehT R Hinds
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H C PalfreyP Greengard
Aug 1, 1981·Cell Calcium·F F Vincenzi
Jan 1, 1980·Annals of the New York Academy of Sciences·J T PennistonT Itano
Jan 1, 1982·Annals of the New York Academy of Sciences·F F Vincenzi
Jan 1, 1982·Annals of the New York Academy of Sciences·B D RoufogalisA M Minocherhomjee
Jan 1, 1986·Annals of the New York Academy of Sciences·C H KeithM L Shelanski
Jan 1, 1982·Annals of the New York Academy of Sciences·B SarkadiG Gárdos
Aug 1, 1995·Thorax·A J Knox, A E Tattersfield
Jan 12, 2001·Physiological Reviews·E E Strehler, D A Zacharias
Jan 1, 1989·Annals of the New York Academy of Sciences·H RasmussenW Bollag
Sep 24, 1982·Biochimica Et Biophysica Acta·O Scharff, B Foder
Aug 1, 1994·Comparative Biochemistry and Physiology. Comparative Physiology·F PalmaC Soverchia
Apr 1, 1983·Cell Calcium·A Clark, E Carafoli
Dec 1, 1995·Cell Calcium·G R Monteith, B D Roufogalis
Jul 1, 1982·Archives of Biochemistry and Biophysics·W H Huang, A Askari
Feb 26, 1988·Science·D L Alkon, H Rasmussen

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