Calmodulin-binding domains in Alzheimer's disease proteins: extending the calcium hypothesis

Biochemical and Biophysical Research Communications
Danton H O'Day, Michael A Myre

Abstract

The calcium hypothesis of Alzheimer's disease (AD) invokes the disruption of calcium signaling as the underlying cause of neuronal dysfunction and ultimately apoptosis. As a primary calcium signal transducer, calmodulin (CaM) responds to cytosolic calcium fluxes by binding to and regulating the activity of target CaM-binding proteins (CaMBPs). Ca(2+)-dependent CaMBPs primarily contain domains (CaMBDs) that can be classified into motifs based upon variations on the basic amphiphilic alpha-helix domain involving conserved hydrophobic residues at positions 1-10, 1-14 or 1-16. In contrast, an IQ or IQ-like domain often mediates Ca(2+)-independent CaM-binding. Based on these attributes, a search for CaMBDs reveals that many of the proteins intimately linked to AD may be calmodulin-binding proteins, opening new avenues for research on this devastating disease.

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Citations

May 30, 2006·Current Microbiology·Praveen Rao Juvvadi, Subramanyam Chivukula
May 10, 2006·Genes, Brain, and Behavior·M GrazinaC Oliveira
Mar 31, 2015·Journal of Alzheimer's Disease : JAD·Danton H O'DayMichael A Myre
Oct 30, 2007·Biochemical and Biophysical Research Communications·Marcus C Schaub, Claus W Heizmann
Apr 14, 2017·Frontiers in Aging Neuroscience·Nady BraidyPerminder S Sachdev
Dec 1, 2010·Molecular Psychiatry·S J FurneyUNKNOWN AddNeuroMed Consortium
Apr 5, 2016·Nature Communications·Diwakar ShuklaVijay S Pande
Jun 21, 2014·Protein Science : a Publication of the Protein Society·Lucas N WaferGeorge I Makhatadze
Nov 2, 2018·Cells·Sabateeshan MathavarajahRobert J Huber
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Nov 1, 2006·The Journal of Biological Chemistry·Matteo PennestriDaniel O Cicero
Feb 2, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Anthony J GriswoldJeffery M Vance
Jul 30, 2021·Journal of Separation Science·Thushara N SamarasingheCarey K Johnson
Apr 25, 2012·Biochimica Et Biophysica Acta·Maria BerrocalAna M Mata

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