Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain

FEBS Letters
Daniel W LambertAnthony J Turner


Angiotensin-converting enzyme-2 (ACE2) is a regulatory protein of the renin-angiotensin system (RAS) and a receptor for the causative agent of severe-acute respiratory syndrome (SARS), the SARS-coronavirus. We have previously shown that ACE2 can be shed from the cell surface in response to phorbol esters by a process involving TNF-alpha converting enzyme (TACE; ADAM17). In this study, we demonstrate that inhibitors of calmodulin also stimulate shedding of the ACE2 ectodomain, a process at least partially mediated by a metalloproteinase. We also show that calmodulin associates with ACE2 and that this interaction is decreased by calmodulin inhibitors.


Jan 30, 2002·The Journal of Biological Chemistry·Chad VickersPeter Tummino
Oct 3, 2002·Journal of the American Chemical Society·Natalie A DalesMichael A Patane
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robson A S SantosThomas Walther
Jan 9, 2004·The Journal of Biological Chemistry·Edward T ParkinNigel M Hooper
Jul 29, 2004·The Journal of Biological Chemistry·Motonari TanakaShigeki Higashiyama
Nov 13, 2004·The Journal of Pathology·A T LelyG J Navis
Jul 8, 2005·Nature·Yumiko ImaiJosef M Penninger
Jul 21, 2005·The Journal of Biological Chemistry·Fumihiko NakamuraPawel T Szymanski
Jul 1, 2006·Kidney International·M C Chappel, C M Ferrario
Sep 21, 2006·American Journal of Physiology. Renal Physiology·Sandra M MalakauskasThu H Le
Dec 15, 2006·Nature·Ursula DanilczykJosef M Penninger
Apr 28, 2007·The Journal of Pathology·I HammingH van Goor
May 30, 2009·The Journal of Biological Chemistry·Dustin SingerFrancois Verrey
Jan 1, 2003·Letters in Peptide Science : LIPS·Fiona J WarnerAnthony J Turner

❮ Previous
Next ❯


Nov 14, 2008·Nature Reviews. Cancer·Gillian Murphy
Nov 4, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Toshihiko HoashiVincent J Hearing
Jan 9, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Toshihiko HoashiVincent J Hearing
Nov 26, 2010·Current Opinion in Nephrology and Hypertension·Chris TikellisWendy C Burns
Feb 26, 2013·Clinical and Experimental Pharmacology & Physiology·Sheila K PatelLouise M Burrell
May 5, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hong Peng JiaPaul B McCray
Apr 27, 2012·International Journal of Peptides·Chris Tikellis, M C Thomas
Feb 28, 2009·Molecular Endocrinology·Sandra M MalakauskasThu H Le
Dec 18, 2013·Journal of Molecular and Cellular Cardiology·Vaibhav B PatelGavin Y Oudit
Jun 22, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan Wysocki, Daniel Batlle
Sep 19, 2009·Cellular and Molecular Life Sciences : CMLS·Daniel W LambertAnthony J Turner
May 16, 2014·Clinical Science·Mariela M GironacciBruno D Cerrato
Sep 28, 2012·Clinical Science·Louise M BurrellSheila K Patel
Feb 26, 2014·Clinical Science·Daniel W LambertAnthony J Turner
Nov 29, 2011·International Journal of Hypertension·Nicola E Clarke, Anthony J Turner
Nov 3, 2016·Frontiers in Physiology·Jiaxi XuMaria S França-Silva
Apr 16, 2016·Circulation Research·Vaibhav B PatelGavin Y Oudit
Apr 17, 2019·Journal of Cellular Physiology·Shrinidh JoshiYagna Pr Jarajapu
Sep 18, 2009·American Journal of Physiology. Cell Physiology·Michikado IwataBarry H Greenberg
Sep 10, 2020·Journal of Cellular Physiology·Mitrasadat RezaeiRamin Pouriran
Jul 15, 2020·Cells·Razie Amraei, Nader Rahimi
Mar 21, 2020·Cell Discovery·Yadi ZhouFeixiong Cheng
Aug 20, 2020·Journal of Translational Medicine·Laure Perrin-CoconPierre-Olivier Vidalain
Jul 23, 2020·European Journal of Clinical Pharmacology·Georgia Ragia, Vangelis G Manolopoulos
Aug 28, 2020·Frontiers in Pharmacology·Thyago M de QueirozEric Lazartigues
Aug 11, 2020·Cellular and Molecular Neurobiology·Alejandro RomeroRussel J Reiter
Nov 11, 2020·Lung·Filippo ScialoAndrea Bianco
Dec 2, 2020·Diseases·Daniel P CardinaliSeithikurippu R Pandi-Perumal

❮ Previous
Next ❯

Datasets Mentioned


Methods Mentioned


Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.