Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart

Experimental Gerontology
Michal M MasternakAndrzej Bartke

Abstract

Blockade of growth hormone (GH), decreased insulin-like growth factor-1 (IGF1) action and increased insulin sensitivity are associated with life extension and an apparent slowing of the aging process. We examined expression of genes involved in insulin action, IR, IRS1, IRS2, IGF1, IGF1R, GLUT4, PPARs and RXRs in the hearts of normal and GHR-/- (KO) mice fed ad libitum or subjected to 30% caloric restriction (CR). CR increased the cardiac expression of IR, IRS1, IGF1, IGF1R and GLUT4 in normal mice and IRS1, GLUT4, PPARalpha and PPARbeta/delta in GHR-KO animals. Expression of IR, IRS1, IRS2, IGF1, GLUT4, PPARgamma and PPARalpha did not differ between GHR-KO and normal mice. These unexpected results suggest that CR may lead to major modifications of insulin action in the heart, but high insulin sensitivity of GHR-KO mice is not associated with alterations in the levels of most of the examined molecules related to intracellular insulin signaling.

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Citations

May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael S BonkowskiAndrzej Bartke
Sep 6, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jorge F GianiFernando P Dominici
Aug 27, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jacob A PaniciMichal M Masternak
Nov 11, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Darlene E BerrymanJohn J Kopchick
Aug 18, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan UngvariAnna Csiszar
Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zoltan Ungvari, Anna Csiszar
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Apr 17, 2013·Physiological Reviews·Andrzej BartkeValter Longo
Nov 1, 2006·Expert Review of Endocrinology & Metabolism·Michal M Masternak, Andrzej Bartke

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