Caloric restriction and the adipokine leptin alter the SDF-1 signaling axis in bone marrow and in bone marrow derived mesenchymal stem cells

Molecular and Cellular Endocrinology
Sudharsan Periyasamy-ThandavanWilliam D Hill

Abstract

Growing evidence suggests that the chemokine stromal cell-derived factor-1 (SDF-1) is essential in regulating bone marrow (BM) derived mesenchymal stromal/stem cell (BMSC) survival, and differentiation to either a pro-osteogenic or pro-adipogenic fate. This study investigates the effects of caloric restriction (CR) and leptin on the SDF-1/CXCR4 axis in bone and BM tissues in the context of age-associated bone loss. For in vivo studies, we collected bone, BM cells and BM interstitial fluid from 12 and 20 month-old C57Bl6 mice fed ad-libitum (AL), and 20-month-old mice on long-term CR with, or without, intraperitoneal injection of leptin for 10 days (10 mg/kg). To mimic conditions of CR in vitro, 18 month murine BMSCs were treated with (1) control (Ctrl): normal proliferation medium, (2) nutrient restriction (NR): low glucose, low serum medium, or (3) NR + leptin: NR medium + 100 ng/ml leptin for 6-48 h. In BMSCs both protein and mRNA expression of SDF-1 and CXCR4 were increased by CR and CR + leptin. In contrast, the alternate SDF-1 receptor CXCR7 was decreased, suggesting a nutrient signaling mediated change in SDF-1 axis signaling in BMSCs. However, in bone SDF-1, CXCR4 and 7 gene expression increase with age and this is rever...Continue Reading

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Citations

Jun 21, 2016·International Journal of Molecular Sciences·Yonghui DongAnmin Chen
Mar 23, 2017·Journal of Bone Metabolism·Mark W Hamrick
Jun 2, 2020·Frontiers in Endocrinology·Andrea Benova, Michaela Tencerova
Sep 11, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sudharsan Periyasamy-ThandavanSadanand Fulzele
Dec 22, 2019·Experimental Gerontology·Jessica L PierceMeghan E McGee-Lawrence

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