Caloric restriction modulates early events in insulin signaling in liver and skeletal muscle of rat

Annals of the New York Academy of Sciences
M ZhuDonald K Ingram

Abstract

Mutations that extend life span in C. elegans suggest that the insulin/IGF-1 signaling (IS) pathway may play a key role in retarding aging and extending life span by caloric restriction (CR). To evaluate this hypothesis, male rats were subjected to either AL (ad libitum) or CR (40% from AL) for 2 and 25 months, and then the effects of CR on the early events in the IS pathway in liver and muscle were assessed. The results indicated that aging was accompanied by a significant decline in insulin receptor tyrosine phosphorylation (pY-IR) upon insulin stimulation in both tissues, which was correlated with a significant increase in the activity of protein tyrosine phosphatase 1B (PTP-1B). However, these alterations with age were attenuated by 25CR. Parallel changes observed in liver mRNA of CR rats were upregulated insulin receptor (IR), IGF-1R and IRS-1, but increased expression of IR mRNA was dissociated with the IR protein in 25CR rats. The expression of liver mRNAs involved in lipid metabolism was also analyzed. In contrast to 25AL rats, the expression of mRNAs for PPARs (alpha, delta, and gamma) was significantly increased in 25CR rats. SREBP-1c and fatty acid synthase were reduced, and other genes were increased, including horm...Continue Reading

References

Jun 1, 2000·Experimental Gerontology·E J Masoro
Sep 7, 2000·Biochemical Pharmacology·B P Kennedy, C Ramachandran
Oct 20, 2001·Journal of Applied Physiology·J F YoungrenR J Barnard
Jan 25, 2002·Annals of the New York Academy of Sciences·G S RothM A Lane

❮ Previous
Next ❯

Citations

Jul 28, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Erik EdströmBrun Ulfhake
Dec 17, 2009·Seminars in Nephrology·Devasmita ChoudhuryMoshe Levi
Aug 11, 2006·Ageing Research Reviews·Bronwen MartinStuart Maudsley
Oct 18, 2005·Mechanisms of Ageing and Development·Amie J Dirks, Christiaan Leeuwenburgh
Jul 9, 2013·Experimental Gerontology·Holly M Brown-Borg, Sharlene Rakoczy
Mar 26, 2013·Experimental Gerontology·Gilles Gouspillou, Russell T Hepple
Sep 8, 2005·American Journal of Physiology. Endocrinology and Metabolism·Malathi SrinivasanMulchand S Patel
Mar 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gabriel F AnhêSilvana Bordin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
G López-LluchRafael de Cabo
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
Ch Sell
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
J Christopher Corton, Holly Brown-Borg
© 2022 Meta ULC. All rights reserved