DOI: 10.1101/514596Jan 9, 2019Paper

Calorie restriction intervention induces enterotype-associated BMI loss in nonobese individuals

BioRxiv : the Preprint Server for Biology
Hua ZouHuanzi Zhong


Calorie restriction (CR), which has the potential effect to weight loss and blood amino acids, has been demonstrated to associate with gut microbiota in human, especially in obese individuals. However, studies for simultaneously evaluating enterotype-dependent impacts of CR on the gut microbiota and blood amino acids in nonobese individuals are still limited. Here, 41 nonobese individuals received a 3-week CR diet with approximately 50% fewer calories than normal diet. We measured their BMI and blood amino acid concentration, along with the gut microbiota before and after the intervention. In this trial, 28 Enterotype Bacteroides (ETB) subjects and 13 Enterotype Prevotella (ETP) subjects were identified before the intervention. Short-term CR dietary intervention decreased the body mass index (BMI) in most subjects but varied in subjects with different enterotypes. ETP subjects exhibited significantly higher BMI loss ratio than the ETB subjects. CR additionally induced substantial enterotype-independent changes in blood amino acids, but only minor changes in gut microbial composition. We further built a prediction model based on baseline relative abundances of 7 gut microbial species showing high performance in predicting CR-ass...Continue Reading

Related Concepts

Clinical Trials
Research Subject
Dietary Modification
Calorie Diet
Allium ramosum
CfxA protein, Prevotella

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