PMID: 109014May 1, 1979

Calories and gastric emptying: a regulatory capacity with implications for feeding

The American Journal of Physiology
P R McHugh, Timothy H Moran


Gastric emptying in four unanesthetized male Macaca mulatta was studied with the serial test meal method of Hunt and Spurrell. Liquid meals were infused into the stomach through a chronic indwelling Silastic cannula. Saline meals empty rapidly and exponentially. Doubling the volume of saline from 150 to 300 ml increased the emptying rate so that the half-life remained unchanged (15 min). The 150-ml glucose meals (0.05, 0.125, and 0.25 g/ml) emptied more slowly than saline, progressively more slowly with increasing concentrations (0.05--1.8, 0.125--0.78, and 0.25--0.37 ml/min) and linearly through most of their course. Doubling the volume of 0.125 g/ml-glucose meal did not change the rate of emptying. Converting grams of glucose to their caloric content, the emptying rate in kcal/min becomes constant (approx 0.4 kcal/min) in this range of concentrations. Isocaloric casein hydrolysate and medium-chain triglyceride oil meals at 0.5 kcal/ml empty at the same rate as glucose. The precision of this regulation is sufficient to give it a role in preabsorptive satiety and the control of caloric intake.


May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mihai CovasaG A Burns
Dec 7, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulrika Smedh, Timothy H Moran
Oct 31, 2006·World Journal of Gastroenterology : WJG·Mohammad Hassan EmamiAbbas Esmaeili
Sep 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy H MoranEllen E Ladenheim
Mar 19, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Karen L JonesMichael Horowitz
Aug 28, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sumito MizuguchiMasataka Majima
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·A NakagawaH Nakabayashi
Jun 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R HayesMihai Covasa
Feb 14, 1998·Journal of Gerontological Nursing·M D Lilley
Aug 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sutep GonlachanvitWilliam L Hasler
Jun 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tanya J LittleJohn T McLaughlin
Jan 6, 2012·The Journal of Physiology·Jozélia G FerreiraIvan E de Araujo

Related Concepts

Energy Intake
Dietary Carbohydrates
Dietary Proteins
Gastric Emptying
Macaca mulatta

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

The Tendon Seed Network

Tendons are rich in the extracellular matrix and are abundant throughout the body providing essential roles including structure and mobility. The transcriptome of tendons is being compiled to understand the micro-anatomical functioning of tendons. Discover the latest research pertaining to the Tendon Seed Network here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Incretins are metabolic hormones that stimulate a decrease in glucose levels in the blood and they have been implicated in glycemic regulation in the remission phase of type 1 diabetes. Here is the latest research.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Long COVID-19

“Long Covid-19” describes illness in patients who are reporting long-lasting effects of the SARS-CoV-19 infection, often long after they have recovered from acute Covid-19. Ongoing health issues often reported include low exercise tolerance and breathing difficulties, chronic tiredness, and mental health problems such as post-traumatic stress disorder and depression. This feed follows the latest research into Long Covid.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.