PMID: 109014May 1, 1979

Calories and gastric emptying: a regulatory capacity with implications for feeding

The American Journal of Physiology
P R McHugh, Timothy H Moran

Abstract

Gastric emptying in four unanesthetized male Macaca mulatta was studied with the serial test meal method of Hunt and Spurrell. Liquid meals were infused into the stomach through a chronic indwelling Silastic cannula. Saline meals empty rapidly and exponentially. Doubling the volume of saline from 150 to 300 ml increased the emptying rate so that the half-life remained unchanged (15 min). The 150-ml glucose meals (0.05, 0.125, and 0.25 g/ml) emptied more slowly than saline, progressively more slowly with increasing concentrations (0.05--1.8, 0.125--0.78, and 0.25--0.37 ml/min) and linearly through most of their course. Doubling the volume of 0.125 g/ml-glucose meal did not change the rate of emptying. Converting grams of glucose to their caloric content, the emptying rate in kcal/min becomes constant (approx 0.4 kcal/min) in this range of concentrations. Isocaloric casein hydrolysate and medium-chain triglyceride oil meals at 0.5 kcal/ml empty at the same rate as glucose. The precision of this regulation is sufficient to give it a role in preabsorptive satiety and the control of caloric intake.

Citations

May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mihai CovasaG A Burns
Dec 7, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulrika Smedh, Timothy H Moran
Oct 31, 2006·World Journal of Gastroenterology : WJG·Mohammad Hassan EmamiAbbas Esmaeili
Sep 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Timothy H MoranEllen E Ladenheim
Mar 19, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Karen L JonesMichael Horowitz
Aug 28, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sumito MizuguchiMasataka Majima
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·A NakagawaH Nakabayashi
Jun 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R HayesMihai Covasa
Feb 14, 1998·Journal of Gerontological Nursing·M D Lilley
Aug 11, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sutep GonlachanvitWilliam L Hasler
Jun 19, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tanya J LittleJohn T McLaughlin
Jan 6, 2012·The Journal of Physiology·Jozélia G FerreiraIvan E de Araujo

Related Concepts

Anthropoidea
Energy Intake
Diet
Dietary Carbohydrates
Ghee
Dietary Proteins
Gastric Emptying
Macaca mulatta
Satiation

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