PMID: 8946783Jan 1, 1996Paper

Calpain as proposed target for neuroprotective treatment of brain ischemia

Folia Neuropathologica
T Zalewska

Abstract

Increasing evidence now suggests that excessive activation of calcium-dependent neutral proteases, calpains, could play a key or contributory role in the pathology of cerebral ischemia. This assumption has been supported in part by the suppressive or neuroprotective effects of calpain inhibitors on post-ischemic damage. Targeting calcium-activated proteolysis could be therefore an alternative strategy for protecting neurons against post-ischemic injury. The data of this review indicate that unregulated activation of calcium-dependent proteolysis plays a significant role in the brain damage that occurs following an ischemic insult and that selective and permanent calpain inhibitors may provide a powerfully effective therapeutic means of limiting neuronal damage.

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

Zhonghua er ke za zhi. Chinese journal of pediatrics
Li-na ChenYu-jia Yao
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Jian LiuLin Guo
Proceedings of the National Academy of Sciences of the United States of America
K S LeeG Lynch
© 2021 Meta ULC. All rights reserved