Calpain in Breast Cancer: Role in Disease Progression and Treatment Response

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Sarah J StorrStewart G Martin

Abstract

The calpains are a family of intracellular cysteine proteases that function in a wide array of cellular activities, including cytoskeletal remodelling, survival and apoptosis. The ubiquitously expressed micro (µ)-calpain and milli (m)-calpain are archetypal family members that require calcium for function and can be inhibited by their endogenous inhibitor calpastatin. This review describes the role of the calpain system in the prognosis of breast cancer and disease progression, in addition to the role of the calpain system in the response to breast cancer treatments, including chemotherapeutic, endocrine and targeted therapies.

Citations

Aug 11, 2020·Breast Cancer Research : BCR·Li LiXiao-Song Wang
Aug 15, 2019·Annual Review of Cell and Developmental Biology·Michael Sheetz
Jan 21, 2021·Biological Reviews of the Cambridge Philosophical Society·Hong Nian, Binyun Ma
Apr 4, 2021·International Journal of Molecular Sciences·Matej VizovisekSimone Schuerle

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