Calpains and human disease

Sub-cellular Biochemistry
I Bertipaglia, E Carafoli

Abstract

Calpains, particularly conventional dimeric calpains, have claimed to be involved in the cell degeneration processes that characterize numerous disease conditions linked to dysfunctions of cellular Ca2+ homeostasis. The evidence supporting their involvement has traditionally been indirect and circumstantial, but recent work has added more solid evidence supporting the role of ubiquitous dimeric calpains in the process of neurodegeneration. The only disease condition in which a calpain defect has been conclusively involved concerns an atypical monomeric calpain: the muscle specific calpain-3, also known as p94. Inactivating defects in its gene cause a muscular dystrophy termed LGMD-2A. The molecular mechanism by which the absence of the proteolytic activity of calpain-3 causes the dystrophic process is unknown. Another atypical calpain, which has been characterized recently as a Ca2(+)-dependent protease, calpain 10, appears To be involved in the etiology of type 2 diabetes. The involvement has been inferred essentially from genetic evidence. Also in the case of type 2 diabetes the molecular mechanisms that could link the disease to calpain 10 are unknown.

Citations

Jun 15, 2011·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Hiroyuki SorimachiYasuko Ono
Jan 10, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Fany BlancMustapha Si-Tahar
Jul 9, 2010·Cellular and Molecular Life Sciences : CMLS·Elisabetta MeacciLucia Formigli
Oct 30, 2010·Experimental Animals·Hiroyuki SorimachiYasuko Ono
Oct 2, 2012·BMC Evolutionary Biology·Sen ZhaoKamran Shalchian-Tabrizi
May 8, 2013·Acta Physiologica·K Hollinger, J T Selsby
Aug 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhi HuangPeter R Hoffmann
Oct 6, 2012·The Biochemical Journal·Robert L Campbell, Peter L Davies
Mar 26, 2011·Expert Opinion on Therapeutic Patents·Isaac O Donkor
Jul 19, 2013·Molecular Biology of the Cell·Marcio FonteneleHelena Araujo
May 12, 2011·PloS One·David A DuVerleHiroshi Mamitsuka
Aug 13, 2013·PLoS Genetics·Kazuo TonamiHiroyuki Sorimachi
Oct 21, 2015·Journal of Alzheimer's Disease : JAD·Mauro FàOttavio Arancio
May 2, 2008·Molecular Neurobiology·Shane D Madden, Thomas G Cotter
Nov 19, 2010·Cellular and Molecular Life Sciences : CMLS·Shang-Min ChouTsai-Kun Li
Oct 18, 2012·Islets·Piero MarchettiLorella Marselli
Oct 21, 2017·PloS One·Margaret H HastingsWayne S Sossin
Oct 1, 2009·Physiological Reviews·Marisa Brini, Ernesto Carafoli
Feb 3, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Marlies Frank, Josef Finsterer
Dec 17, 2008·Journal of Medicinal Chemistry·Kyle A RasbachRick G Schnellmann
May 7, 2008·Biochemical and Biophysical Research Communications·Christopher J Giguere, Rick G Schnellmann
Apr 4, 2009·Toxicon : Official Journal of the International Society on Toxinology·Erik TedescoCesare Montecucco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.