Calprotectin, a new biomarker for diagnosis of acute respiratory infections.

Scientific Reports
Aleksandra HavelkaAnders Larsson

Abstract

Respiratory tract infections require early diagnosis and adequate treatment. With the antibiotic overuse and increment in antibiotic resistance there is an increased need to accurately distinguish between bacterial and viral infections. We investigated the diagnostic performance of calprotectin in respiratory tract infections and compared it with the performance of heparin binding protein (HBP) and procalcitonin (PCT). Biomarkers were analyzed in patients with viral respiratory infections and patients with bacterial pneumonia, mycoplasma pneumonia and streptococcal tonsillitis (n = 135). Results were compared with values obtained from 144 healthy controls. All biomarkers were elevated in bacterial and viral infections compared to healthy controls. Calprotectin was significantly increased in patients with bacterial infections; bacterial pneumonia, mycoplasma pneumonia and streptococcal tonsillitis compared with viral infections. PCT was significantly elevated in patients with bacterial pneumonia compared to viral infections but not in streptococcal tonsillitis or mycoplasma caused infections. HBP was not able to distinguish between bacterial and viral causes of infections. The overall clinical performance of calprotectin in the ...Continue Reading

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Citations

Apr 3, 2020·Infection & chemotherapy·Mi Hee Kim, Jung Hyun Choi
Sep 26, 2020·Frontiers in Immunology·Mahadevappa HemshekharNeeloffer Mookherjee
Nov 10, 2020·Journal of Immunological Methods·Per VengeKarlis Pauksen
Apr 4, 2021·Biomedicines·Kieran LeongMichael T McCurdy
Apr 20, 2021·Analytica Chimica Acta·Laís Canniatti BrazacaEmanuel Carrilho
Jun 3, 2021·Children·Grigorios Chatziparasidis, Ahmad Kantar
Jun 15, 2021·Blood Cells, Molecules & Diseases·Alan Ledif Reyes MondragónDavid Gómez-Almaguer
Sep 24, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Martin WollmerToralph Ruge

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Methods Mentioned

BETA
PCR
ELISA
X-ray

Software Mentioned

MedCalc

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