Calprotectin in Daily Practice: Where Do We Stand in 2017?

Digestion
Fabrizia D'AngeloJean Louis Frossard

Abstract

To make a distinction between organic and functional disease is essential for gastroenterologists in their daily practice, but it may be challenging, given the variety and aspecificity of gastrointestinal symptoms among the general population. The clinician aim is to avoid diagnostic delay and to restrict unnecessary invasive and expensive exams. Faecal markers, in particular faecal calprotectin (FC), have given proof of being reliable markers of intestinal inflammation with good clinical sensitivity. Calprotectin is useful in the differential diagnosis between inflammatory bowel disease and irritable bowel syndrome, as well as in the follow-up of inflammatory bowel disease patients and in predicting treatment response, with an excellent correlation with endoscopic activity. Its role in collagenous colitis and infectious colitis is less clear and still under investigation. Key Message: Despite the growing evidence supporting its use, many clinicians are uncomfortable in dosing FC, due to its low specificity and the variability of cut-off values. Indeed there are no clear guidelines about how to manage patients with intermediate levels of FC. The aim of this article is to review recent literature on calprotectin and its use. The...Continue Reading

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Citations

Jul 24, 2018·Allergy·Eliete Neves Silva GuerraHélène Chardin
Nov 20, 2018·European Journal of Clinical Investigation·Balázs SzirmayTamás Kőszegi
May 24, 2019·Scandinavian Cardiovascular Journal : SCJ·Kasper PrydsRoni Ranghøj Nielsen
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Apr 22, 2020·Journal of Paediatrics and Child Health·Marina MitrogiorgouSmaragdi Fessatou
May 23, 2020·Clinical and Experimental Gastroenterology·Matt DavieAnastasios Koulaouzidis
Feb 21, 2021·BMC Bioinformatics·Janet C SiebertCarsten Görg
Jul 27, 2021·Frontiers in Pharmacology·Jing ZhouSimin Chen

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