Calprotectin (S100A8/A9) and S100A12 are associated with measures of disease activity in a longitudinal study of patients with rheumatoid arthritis treated with infliximab

Scandinavian Journal of Rheumatology
H H NordalA-K Halse

Abstract

The pro-inflammatory proteins calprotectin (a heterocomplex of S100A8/A9) and S100A12 have been associated with disease activity in rheumatoid arthritis (RA). The aim of this study was to compare their potential as biomarkers in a prospective study of RA patients starting with infliximab as their first biological disease-modifying anti-rheumatic drug (DMARD). Thirty-nine RA patients were examined and serum samples collected when starting with infliximab and after 3, 6, and 12 months. Calprotectin and S100A12 were analysed by enzyme-linked immunosorbent assays (ELISAs) and, together with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), measured at all time points. A disease activity score of 28 joints (DAS28) was calculated. Radiographs of the hands, wrists, and feet were taken at baseline and after 3 years, and assessed according to the modified Sharp/van der Heijde (SvH) score. Responsiveness was evaluated according to the European League of Associations for Rheumatology (EULAR) response criteria based on 28 joints. Both S100 proteins were significantly higher in seropositive than in seronegative patients (p = 0.01). Calprotectin correlated significantly with CRP (ρ = 0.51-0.75), ESR (ρ = 0.32-0.52), and DAS2...Continue Reading

References

Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·H B BerntzenM K Fagerhol
Jun 9, 1965·Biochemical and Biophysical Research Communications·B W Moore
Dec 21, 2002·Scandinavian Journal of Rheumatology·Tor Magne MadlandJohan G Brun
May 20, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dirk FoellJohannes Roth
Sep 1, 2004·Biochemical and Biophysical Research Communications·Ingo MarenholzGünter Fritz
Dec 14, 2004·Arthritis and Rheumatism·Dirk Foell, Johannes Roth
Jan 16, 2007·Annals of the Rheumatic Diseases·Helmut WittkowskiJohannes Roth
Jan 30, 2007·Scandinavian Journal of Immunology·A LarsenM K Fagerhol
Sep 29, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Anne Grimstvedt KvalvikJohan Gorgas Brun
Jul 28, 2012·Current Molecular Medicine·R DonatoC L Geczy
Jan 19, 2013·Molecular Diagnosis & Therapy·Miriam García-AriasAlejandro Balsa
Apr 17, 2015·Rheumatology·Victoria Navarro-CompánDésirée van der Heijde

❮ Previous
Next ❯

Citations

Aug 18, 2017·Annals of the Rheumatic Diseases·Maria Karolina JonssonEspen A Haavardsholm
Apr 18, 2019·Laboratory Medicine·Kohki OkadaMasaki Ikemoto
Dec 28, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Hilde Haugedal NordalHilde Berner Hammer
Dec 18, 2019·Arthritis Research & Therapy·Mikael BrinkSolbritt Rantapää-Dahlqvist
Aug 5, 2018·Nature Reviews. Rheumatology·Judith AustermannJohannes Roth
Feb 25, 2021·Expert Review of Clinical Immunology·Ikram MezghicheElisabetta Bianchi
Feb 20, 2021·Frontiers in Pharmacology·Varvara ChoidaCoziana Ciurtin
Mar 11, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marnix MylemansLieve Van Hoovels
Jun 10, 2018·Joint, Bone, Spine : Revue Du Rhumatisme·Minh Vu Chuong NguyenPhilippe Gaudin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.