Calreticulin in human pregnancy and pre-eclampsia

Molecular Human Reproduction
V Y GuN M Gude

Abstract

Pre-eclampsia is a disorder of human pregnancy that involves pregnancy-induced maternal hypertension and proteinuria. Evidence indicates that pre-eclampsia involves widespread activation of maternal endothelial cells. Calreticulin is a ubiquitously expressed, multi-functional protein that has been shown to have both pro- and anti-inflammatory effects on cultured endothelial cells in vitro and in whole animals. In order to clarify the role of this protein in normal human pregnancy and in pre-eclampsia, this study has measured expression of calreticulin in maternal blood and in placenta in patients with pre-eclampsia and in control pregnancies. There was a significant increase (approximately 5-fold) in calreticulin in plasma in term pregnant women compared with women who were not pregnant. There was no difference, however, in calreticulin in plasma from women who were sampled at first trimester, second trimester and at term. In addition, there was a significant increase (approximately 50%) in calreticulin in plasma from pre-eclamptic women compared to controls. Calreticulin mRNA and protein expression in placenta were not changed between pre-eclampsia and control pregnancies. These novel results indicate that calreticulin is incr...Continue Reading

References

Aug 1, 1992·The Biochemical Journal·M MichalakM Opas
Nov 27, 1995·FEBS Letters·S BakshM Michalak
Mar 1, 1997·The Biochemical Journal·U KishoreP Eggleton
Jan 1, 1997·Lupus·P EggletonR D Sontheimer
Apr 29, 1998·Current Opinion in Obstetrics & Gynecology·J R Higgins, S P Brennecke
Nov 24, 1998·Histochemistry and Cell Biology·B HuppertzP Kaufmann
Nov 24, 1999·The Biochemical Journal·M MichalakM Opas
Aug 10, 2000·American Journal of Hypertension·K KistersM Kosch
Aug 31, 2000·The Journal of Biological Chemistry·S GoicoecheaJ E Murphy-Ullrich
Mar 10, 2001·Obstetrics and Gynecology·J R MellembakkenV Videm
Apr 18, 2001·Trends in Cell Biology·S JohnsonP Eggleton
Aug 14, 2003·The Medical Journal of Australia·Mark A Brown
Oct 2, 2003·Journal of the Society for Gynecologic Investigation·Kora HirtenlehnerMartin Knöfler
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
Nov 5, 2004·Molecular and Cellular Biochemistry·Marek MichalakMichal Opas
Jun 11, 2005·Science·Christopher W Redman, Ian L Sargent
Aug 30, 2005·International Review of Cytology·Karen BedardMichal Opas
Mar 9, 2006·American Journal of Obstetrics and Gynecology·José VillarUNKNOWN World Health Organization Calcium Supplementation for the Prevention of Preeclampsia Trial Group
Jun 6, 2006·Nature Medicine·Shivalingappa VenkateshaS Ananth Karumanchi
Sep 27, 2006·The Journal of Cell Biology·Saumen PalEmery H Bresnick
Aug 1, 2004·Molecular and Cellular Biochemistry·Marek MichalakMichal Opas

❮ Previous
Next ❯

Citations

Feb 9, 2013·Pathology Oncology Research : POR·Mohammadreza ZamanianRozita Rosli
Apr 7, 2009·Molecular Human Reproduction·M HassaneinR W Mason
Nov 27, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Leslie I GoldJoanne E Murphy-Ullrich
Nov 28, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ajit KumarLuciano Saso
Jul 28, 2016·Frontiers in Immunology·Galia Ramírez-TolozaArturo Ferreira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.