Calreticulin: non-endoplasmic reticulum functions in physiology and disease.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Leslie I GoldJoanne E Murphy-Ullrich

Abstract

Calreticulin (CRT), when localized to the endoplasmic reticulum (ER), has important functions in directing proper conformation of proteins and glycoproteins, as well as in homeostatic control of cytosolic and ER calcium levels. There is also steadily accumulating evidence for diverse roles for CRT localized outside the ER, including data suggesting important roles for CRT localized to the outer cell surface of a variety of cell types, in the cytosol, and in the extracellular matrix (ECM). Furthermore, the addition of exogenous CRT rescues numerous CRT-driven functions, such as adhesion, migration, phagocytosis, and immunoregulatory functions of CRT-null cells. Recent studies show that topically applied CRT has diverse and profound biological effects that enhance cutaneous wound healing in animal models. This evidence for extracellular bioactivities of CRT has provided new insights into this classically ER-resident protein, despite a lack of knowledge of how CRT exits from the ER to the cell surface or how it is released into the extracellular milieu. Nonetheless, it has become clear that CRT is a multicompartmental protein that regulates a wide array of cellular responses important in physiological and pathological processes, s...Continue Reading

References

Dec 1, 1990·Biochemical Society Transactions·R MalhotraK B Reid
Dec 1, 1987·The Journal of Investigative Dermatology·G J RaugiA M Gown
Oct 1, 1994·Current Opinion in Cell Biology·J Gailit, R A Clark
Jul 7, 1995·The Journal of Biological Chemistry·T K WhiteM L Tanzer
Sep 1, 1994·Clinical Immunology and Immunopathology·P EggletonA I Tauber
Feb 1, 1994·The Journal of Cell Biology·S M Frisch, H Francis
Apr 5, 1996·The Journal of Biological Chemistry·J M McDonnellM L Tanzer
Mar 17, 1997·Biochemical and Biophysical Research Communications·Q ZhuM L Tanzer
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·E DaiA Lucas
Jul 10, 1998·Cell·S E CrawfordN Bouck
Dec 22, 1998·The Journal of Experimental Medicine·S E PikeG Tosato
Mar 23, 1999·The Journal of Cell Biology·N MesaeliM Michalak
May 13, 1999·Scandinavian Journal of Immunology·P Eggleton, D H Llewellyn
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Oct 12, 1999·The American Journal of Physiology·J M PatelE R Block
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·M G Coppolino, S Dedhar
Mar 31, 2000·Experimental Cell Research·F RauchR St-Arnaud
Jun 8, 2000·The Journal of Biological Chemistry·E F CorbettM Michalak
Aug 31, 2000·The Journal of Biological Chemistry·S GoicoecheaJ E Murphy-Ullrich
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z LiD Roberts
Apr 4, 2001·The Journal of Clinical Investigation·J E Murphy-Ullrich
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·S OyadomariM Mori
Sep 7, 2001·Current Opinion in Cell Biology·S M Frisch, R A Screaton
Nov 17, 2001·The Journal of Investigative Dermatology·B Lange-AsschenfeldtM Detmar
Dec 1, 2001·The EMBO Journal·A Müller-TaubenbergerG Gerisch
Mar 30, 2002·The Journal of Biological Chemistry·Anthony Wayne OrrJoanne E Murphy-Ullrich
Apr 23, 2002·Traffic·Willem StoorvogelGraça Raposo
Jul 31, 2002·The Journal of Biological Chemistry·Silvia GoicoecheaJoanne E Murphy-Ullrich
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·R William VandivierKelly E Greene
May 24, 2003·Biochemical and Biophysical Research Communications·Jeffrey P RabekJohn Papaconstantinou

❮ Previous
Next ❯

Citations

Sep 20, 2012·Bioconjugate Chemistry·Bryan A Smith, Bradley D Smith
May 18, 2013·Cell Death & Disease·O KryskoD V Krysko
Dec 12, 2013·The New England Journal of Medicine·J NangaliaA R Green
Oct 1, 2010·The Journal of Biological Chemistry·Guennadi KozlovKalle Gehring
Dec 24, 2010·The Journal of Biological Chemistry·Sanjeeva J WijeyesakereMalini Raghavan
Sep 14, 2011·Molecular & Cellular Proteomics : MCP·Sudip KhadkaDouglas J LaCount
Sep 29, 2012·Science·Laura SenovillaGuido Kroemer
Sep 5, 2013·Molecular and Cellular Biology·Chi-Chao LiuChinten James Lim
Jun 15, 2013·Proteome Science·Enbing TianQingtao Wang
Nov 21, 2013·Acta Neuropathologica Communications·Mary Ní FhlathartaighUna Fitzgerald
Jul 30, 2014·PloS One·Cristina Bilbao-SieyroMaria Teresa Gomez-Casares
Jan 18, 2014·Nature Protocols·Jan M SuskiMariusz R Wieckowski
Feb 18, 2014·The Journal of Clinical Investigation·Yoko KojimaNicholas J Leeper
Jan 9, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·María Dolores SaavedraRaquel Romar
Apr 10, 2013·The International Journal of Biochemistry & Cell Biology·Marcos A CarpioMarta E Hallak
Sep 6, 2014·Best Practice & Research. Clinical Haematology·Raajit Rampal, Ross L Levine
Aug 21, 2014·Mediators of Inflammation·Beatriz SangiulianoJosé E Belizário
Jan 5, 2011·Biochemistry Research International·Susana J OliveiraJorge P Pinto
Nov 20, 2012·Annual Review of Immunology·Guido KroemerLaurence Zitvogel
Jan 1, 2013·Cellular and Molecular Life Sciences : CMLS·Mohammad SalemOle Haagen Nielsen
Feb 9, 2013·Pathology Oncology Research : POR·Mohammadreza ZamanianRozita Rosli
Nov 16, 2011·Cancer Immunology, Immunotherapy : CII·Rongrong LiuBoquan Jin
Jul 26, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Takatoshi KarasawaPeter S Steyger
Apr 25, 2012·Cell and Tissue Research·Kristian PrydzJaakko Saraste
Jan 22, 2011·Expert Opinion on Therapeutic Patents·Hee-Jeong ChoYoung Bong Kim
Aug 1, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qian WangMarek Michalak
May 23, 2014·Expert Review of Hematology·Paola GuglielmelliAlessandro M Vannucchi
Sep 18, 2014·Membranes·Yue JiangHiroaki Matsunami
Aug 1, 2015·FEBS Letters·Julio J Caramelo, Armando J Parodi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.