Calretinin expression in hilar mossy cells of the hippocampal dentate gyrus of nonhuman primates and humans

Hippocampus
L SeressC Leranth

Abstract

Mossy cells, the major excitatory neurons of the hilus of the dentate gyrus constitutively express calretinin in several rodent species, including mouse and hamster, but not in rats. Several studies suggest that mossy cells of the monkey dentate gyrus are calretinin-positive, but others have reported mossy cells in monkeys to be devoid of detectable calretinin-like immunoreactivity. In the present study, the hilar region was investigated throughout the entire longitudinal extent of the hippocampal dentate gyrus in both Old World and New World monkeys, as well as in humans. In the examined four monkey species, mossy cells were found to be calretinin-positive at the uncal pole and at variable length within the main body of the dentate gyrus but not in the tail part. The associational pathway, formed by axons of mossy cells in the inner dentate molecular layer was calretinin-positive in more caudal sections, suggesting that mossy cell axon terminals may contain calretinin, whereas mossy cell somata may contain calretinin in a concentration too low to be detected by immunocytochemistry. In contrast, human mossy cells appear to be devoid of calretinin immunoreactivity in both their somata and their axon terminals. Taken together, mo...Continue Reading

References

Dec 15, 1978·The Journal of Comparative Neurology·D G Amaral
Feb 1, 1994·Hippocampus·E Soriano, M Frotscher
Sep 25, 1995·The Journal of Comparative Neurology·R Nitsch, T G Ohm
Mar 4, 1996·The Journal of Comparative Neurology·P S BuckmasterP A Schwartzkroin
Mar 1, 1996·Journal of Neuropathology and Experimental Neurology·I BlumckeO D Wiestler
Mar 1, 1997·The European Journal of Neuroscience·A SikG Buzsáki
Dec 31, 1997·The European Journal of Neuroscience·T F FreundI Katona
Apr 4, 1998·The Journal of Comparative Neurology·E O KoyluM J Kuhar
Sep 22, 2000·Epilepsia·I BlümckeO D Wiestler
Jan 3, 2001·The Journal of Comparative Neurology·P S Buckmaster, D G Amaral

❮ Previous
Next ❯

Citations

Mar 1, 2012·PloS One·Minjung KimXianjin Zhou
Apr 28, 2009·Journal of Neurosurgery·Kim J Burchiel
Jun 4, 2013·Brain Structure & Function·Nina PatzkePaul R Manger
Mar 26, 2016·Frontiers in Neuroanatomy·R Maarten van DijkIrmgard Amrein
Oct 11, 2008·The Journal of Comparative Neurology·Hideki KondoDavid G Amaral
Oct 31, 2008·The Journal of Comparative Neurology·Pierre LavenexDavid G Amaral
Aug 19, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Joan S BaizerPatrick R Hof
Oct 18, 2014·Frontiers in Neuroanatomy·Kinga Tóth, Zsófia Maglóczky
Mar 13, 2019·Journal of Anatomy·Gundela MeyerMiriam González-Gómez
Nov 22, 2018·Frontiers in Molecular Neuroscience·Christina T LaGammaChristine A Denny
Dec 3, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Brendan SullivanKebreten F Manaye
Jul 30, 2021·Neuroscience Bulletin·Yingbei QiZhong Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
George GlassJames W Mandell
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Daniel PiriciRadu Stanescu
© 2021 Meta ULC. All rights reserved