PMID: 9526028Apr 4, 1998Paper

Calretinin gene expression in the human thalamus

Brain Research. Molecular Brain Research
F CicchettiA Parent

Abstract

The localization and levels of expression of the calcium-binding protein calretinin (CR) in the human thalamus was studied with an in situ hybridization method applied to formalin-fixed postmortem material from normal individuals. The riboprobe used was generated from a specific fragment of human CR cDNA. As visualized on X-ray film autoradiographs, high levels of CR gene transcript occurred in several thalamic nuclei, including the reticular nucleus, mediodorsal nucleus, rostral intralaminar nuclei (paracentral, central medial and central lateral) and several midline nuclei (paraventricular, reuniens and medioventral nuclei). In the reticular nucleus, neurons expressing CR mRNA were few in number but formed dense and widely distributed clusters. In contrast, virtually all neurons in the rostral intralaminar and midline nuclei expressed very high levels of CR mRNA and formed a prominent rim around the mediodorsal nucleus, which contained scattered clusters of labeled neurons. The caudal intralaminar nuclei, principally the centromedian nucleus, displayed very few neurons expressing CR mRNA. Only the medial part of the parafascicular nucleus expressed moderate levels of CR mRNA. The nuclei of the ventral group (ventral anterior,...Continue Reading

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Citations

Nov 24, 1999·Journal of Chemical Neuroanatomy·T C Nag, S Wadhwa
Oct 4, 2011·Journal of Physiology, Paris·Michele PignatelliXavier Leinekugel
Jun 22, 2007·Brain Research·Fahad E Rahman, Joan S Baizer
Aug 27, 2016·Frontiers in Neuroanatomy·Emmanuel Márquez-LegorretaEnrique Saldaña
Oct 15, 2008·PloS One·Raúl Alelú-PazJosé Manuel Giménez-Amaya
Apr 12, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rahul C BhoyarSaikat Biswas

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