Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point

Development
Tobias AltherEsther T Stoeckli

Abstract

Axon guidance at choice points depends on the precise regulation of guidance receptors on the growth cone surface. Upon arrival at the intermediate target or choice point, a switch from attraction to repulsion is required for the axon to move on. Dorsal commissural (dI1) axons crossing the ventral midline of the spinal cord in the floor plate represent a convenient model for the analysis of the molecular mechanism underlying the switch in axonal behavior. We identified in chick a role for calsyntenin 1 in the regulation of vesicular trafficking of guidance receptors in dI1 axons at choice points. In cooperation with RabGDI, calsyntenin 1 shuttles Rab11-positive vesicles containing Robo1 to the growth cone surface in a precisely regulated manner. By contrast, calsyntenin 1-mediated trafficking of frizzled 3, a guidance receptor in the Wnt pathway, is independent of RabGDI. Thus, tightly regulated insertion of guidance receptors, which is required for midline crossing and the subsequent turn into the longitudinal axis, is achieved by specific trafficking.

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Citations

Sep 25, 2017·Journal of Cell Science·Richard EvaJames W Fawcett
May 16, 2018·Development·Esther T Stoeckli
May 19, 2018·Small GTPases·Bart Nieuwenhuis, Richard Eva
Sep 1, 2016·Development·Heike Blockus, Alain Chédotal
Feb 7, 2017·F1000Research·Esther Stoeckli
Jan 25, 2019·Development·Mariko Kinoshita-KawadaJane Y Wu
Sep 16, 2017·Frontiers in Neuroanatomy·Gemma de Ramon FrancàsEsther T Stoeckli
Dec 16, 2018·Cellular and Molecular Life Sciences : CMLS·Natalia Colás-Algora, Jaime Millán
Mar 5, 2020·Cell Death & Disease·Yuki NakanoYoshiaki Kiuchi
Jan 14, 2021·The Journal of Comparative Neurology·Alexandre DumoulinEsther T Stoeckli
Dec 27, 2017·Seminars in Cell & Developmental Biology·Hugo DucuingValérie Castellani

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