Abstract
The tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. The current study aims to provide the first step towards a science-based evidence of the beneficial effects of C. spruceanum in the promotion of longevity and in the modulation of age-related markers. For this investigation, we used the model system Caenorhabditis elegans to evaluate in vivo antioxidant and anti-aging activity of a water extract from C. spruceanum. To chemically characterize the extract, HPLC MS (High Performance Liquid Chromatography Mass Spectrometry)/MS analyses were performed. Five secondary metabolites were identified in the extract, namely gardenoside, 5-hydroxymorin, cyanidin, taxifolin, and 5-hydroxy-6-methoxycoumarin-7-glucoside. C. spruceanum extract was able to enhance stress resistance and to extend lifespan along with attenuation of aging-associated markers in C. elegans. The demonstrated bioactivities apparently depend on the DAF-16/FOXO pathw...Continue Reading
References
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman
Dec 2, 1993·Nature·C KenyonR Tabtiang
May 30, 2001·Journal of Ethnopharmacology·A PortilloS Cañigueral
Aug 29, 2003·Phytochemistry·Luz Margarita Cardona ZuletaVanderlan da Silva Bolzani
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amy StrayerYuan Luo
Oct 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michelangela BarbieriGiuseppe Paolisso
Jan 11, 2005·The American Journal of Clinical Nutrition·Augustin ScalbertMike Saltmarsh
Mar 8, 2005·The Journal of Biological Chemistry·Margie T BorraJohn M Denu
Aug 11, 2006·The Journal of Endocrinology·Ralf BaumeisterMaren Hertweck
Jan 31, 2007·Annals of the New York Academy of Sciences·Giuseppina CandoreCalogero Caruso
Dec 1, 2007·WormBook : the Online Review of C. Elegans Biology·Theresa Stiernagle
Dec 9, 2008·Free Radical Biology & Medicine·Longze ZhangBaolu Zhao
Feb 17, 2010·Aging·William R Swindell
Mar 30, 2010·Clinics in Dermatology·Mahreen Ameen
Jan 1, 2010·Cell Death & Disease·E MorselliG Kroemer
Dec 12, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wei ChenMichael Wink
Apr 23, 2013·The Journal of Pharmacy and Pharmacology·Wei ChenMichael Wink
Jan 21, 2014·Chinese Medicine·Mohamed L AshourMichael Wink
Jan 1, 2014·Antioxidants·Sami Abbas, Michael Wink
Jan 27, 2016·Journal of Agricultural and Food Chemistry·Herbenya Silva PeixotoMichael Wink
Feb 28, 2016·BMC Complementary and Alternative Medicine·Fabiano S de VargasEmerson S Lima
Sep 21, 2017·Medicines·Herbenya PeixotoMichael Wink
Citations
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nora TawfeekMichael Wink
Jul 10, 2019·BMC Complementary and Alternative Medicine·Panthakarn RangsinthTewin Tencomnao
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Herbenya PeixotoMichael Wink
Sep 11, 2020·Oxidative Medicine and Cellular Longevity·Mariana RoxoMichael Wink
Jun 9, 2020·Biogerontology·Min LuGui-Sheng Wu
Jul 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara ThabitMichael Wink
Mar 9, 2021·Biogerontology·Nadine SaulGeorg Fuellen
May 15, 2021·Oxidative Medicine and Cellular Longevity·Maria Lúcia da Silva CordeiroKatia Castanho Scortecci
Jun 29, 2021·Journal of Ethnopharmacology·Tian-Feng LinYan-Yan Jiang