Calycophyllum spruceanum (Benth.), the Amazonian "Tree of Youth" Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Herbenya PeixotoMichael Wink

Abstract

The tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. The current study aims to provide the first step towards a science-based evidence of the beneficial effects of C. spruceanum in the promotion of longevity and in the modulation of age-related markers. For this investigation, we used the model system Caenorhabditis elegans to evaluate in vivo antioxidant and anti-aging activity of a water extract from C. spruceanum. To chemically characterize the extract, HPLC MS (High Performance Liquid Chromatography Mass Spectrometry)/MS analyses were performed. Five secondary metabolites were identified in the extract, namely gardenoside, 5-hydroxymorin, cyanidin, taxifolin, and 5-hydroxy-6-methoxycoumarin-7-glucoside. C. spruceanum extract was able to enhance stress resistance and to extend lifespan along with attenuation of aging-associated markers in C. elegans. The demonstrated bioactivities apparently depend on the DAF-16/FOXO pathw...Continue Reading

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Citations

May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nora TawfeekMichael Wink
Jul 10, 2019·BMC Complementary and Alternative Medicine·Panthakarn RangsinthTewin Tencomnao
Mar 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Herbenya PeixotoMichael Wink
Jul 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara ThabitMichael Wink
May 15, 2021·Oxidative Medicine and Cellular Longevity·Maria Lúcia da Silva CordeiroKatia Castanho Scortecci

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Datasets Mentioned

BETA
P8635

Methods Mentioned

BETA
Assay
fluorescence microscopy

Software Mentioned

Graphpad Prism
GraphPad
Xcalibur
Image J

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