Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling

Journal of Experimental & Clinical Cancer Research : CR
Jing TianJian Chen

Abstract

Clinically, breast cancer is generally classified into estrogen receptor-positive (ER+) or estrogen receptor-negative (ER-) subtypes. The phytoestrogen calycosin has been shown to inhibit the proliferation of ER+ cells, which may be mediated by a feedback loop that involves miR-375, RAS dexamethasone-induced 1 (RASD1), and ERα. However, how calycosin acts on ER- breast cancer cells remains unclear. Here, we show that calycosin inhibited the proliferation of both ER- (MDA-MB-468 and SKBR3) and ER+ breast cancer cells (MCF-7 and T47D) and that these inhibitory effects were associated with the up-regulation of the long non-coding RNA (lncRNA) WDR7-7. For the first time, we demonstrate that the expression of WDR7-7 is reduced in breast cancer cell lines and that the overexpression of WDR7-7 inhibits growth through a mechanism that involves G-protein coupled estrogen receptor 30 (GPR30). Meanwhile, we show that calycosin stimulated the WDR7-7-GPR30 signaling pathway in MCF-7, T47D, MDA-MB-468, and SKBR3 breast cancer cells. In contrast, in MCF10A and GPR30-deficient MDA-MB-231 cells, due to a lack of WDR7-7-GPR30 for activation, calycosin failed to inhibit cell growth. Additionally, in all four GPR30-positive breast cancer lines, ca...Continue Reading

References

Jan 21, 2006·Cancer Research·Charles E WoodJ Mark Cline
Mar 3, 2006·The Journal of Clinical Investigation·Bonnie J Deroo, Kenneth S Korach
Oct 21, 2010·Endocrine·Dengfeng WangChen Chen
Nov 3, 2010·Journal of Experimental & Clinical Cancer Research : CR·Wen-zhong WangJian-xin Gu
Feb 1, 2012·Breast Cancer Research and Treatment·Rainer GirgertCarsten Gründker
Mar 15, 2012·Current Cancer Drug Targets·R LappanoM Maggiolini
May 5, 2012·Journal of Experimental & Clinical Cancer Research : CR·Zhinong JiangLinbo Wang
Mar 29, 2013·Cancer Research·Kristen N StevensFergus J Couch
Apr 24, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J TianJ Chen
Feb 21, 2014·Journal of Cancer Research and Clinical Oncology·Christine WeißenbornAtanas Ignatov
Mar 13, 2014·Current Pharmaceutical Design·Pilar RocaJordi Oliver
May 17, 2014·Frontiers in Endocrinology·Rosamaria LappanoMarcello Maggiolini
Aug 28, 2014·European Journal of Pharmacology·Alexander V Sirotkin, Abdel Halim Harrath
Sep 27, 2014·International Journal of Molecular Sciences·Chen WangJi-Min Cao
Oct 11, 2014·World Journal of Clinical Oncology·Iqra BilalSaffron Whitehead
Oct 30, 2015·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Nov 26, 2015·Food Chemistry·Maria RussoSeyed Mohammad Nabavi
Dec 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alina UifăleanCristina Adela Iuga
Mar 13, 2016·Hormones & Cancer·Cameron P CapperRichard J Auchus
May 24, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giovanni LavorgnaMatteo Bellone
Nov 4, 2016·International Journal of Environmental Research and Public Health·Lauren C HoughtonRebecca Troisi
Mar 7, 2017·Cancer·Omer Kucuk

❮ Previous
Next ❯

Citations

Jun 5, 2019·Journal of Cellular and Molecular Medicine·Rong LiXiaoxi Zhang
Apr 12, 2019·Combinatorial Chemistry & High Throughput Screening·Xiang LiuYing Zhang
Nov 22, 2019·Frontiers in Endocrinology·Prathibha RanganathanSughosha Nambiar
Mar 20, 2020·Molecular Cancer·Francesca CrudeleStefano Volinia
Dec 14, 2018·Clinical Science·Luis MolinaPamela Ehrenfeld
Jan 5, 2018·Journal of Experimental & Clinical Cancer Research : CR·Jing TianJian Chen
Nov 27, 2020·International Journal of Molecular Sciences·Eleonora A BragaNikolay E Kushlinskii
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Min XinYanhong Guo
Apr 13, 2021·Stress : the International Journal on the Biology of Stress·Chad D ForadoriRobert J Kemppainen
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Guowei GongZhen Wen
Jul 3, 2021·International Journal of Molecular Sciences·Elena A FilippovaEleonora A Braga
Jul 3, 2021·Biomedicines·Mihaela Raluca RaduViorica Elena Rădoi
May 18, 2021·Molecular and Cellular Biochemistry·Yao Tang, Xiusheng He
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lingping KongAnzhou Tang
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhengzhao LiJianfeng Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
Feature Extraction
transfection
xenograft
xenografts

Software Mentioned

Pro Plus
SPSS
ABI 7500
Image
Agilent Feature Extraction

Related Concepts

Related Feeds

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.