Abstract
Clinically, breast cancer is generally classified into estrogen receptor-positive (ER+) or estrogen receptor-negative (ER-) subtypes. The phytoestrogen calycosin has been shown to inhibit the proliferation of ER+ cells, which may be mediated by a feedback loop that involves miR-375, RAS dexamethasone-induced 1 (RASD1), and ERα. However, how calycosin acts on ER- breast cancer cells remains unclear. Here, we show that calycosin inhibited the proliferation of both ER- (MDA-MB-468 and SKBR3) and ER+ breast cancer cells (MCF-7 and T47D) and that these inhibitory effects were associated with the up-regulation of the long non-coding RNA (lncRNA) WDR7-7. For the first time, we demonstrate that the expression of WDR7-7 is reduced in breast cancer cell lines and that the overexpression of WDR7-7 inhibits growth through a mechanism that involves G-protein coupled estrogen receptor 30 (GPR30). Meanwhile, we show that calycosin stimulated the WDR7-7-GPR30 signaling pathway in MCF-7, T47D, MDA-MB-468, and SKBR3 breast cancer cells. In contrast, in MCF10A and GPR30-deficient MDA-MB-231 cells, due to a lack of WDR7-7-GPR30 for activation, calycosin failed to inhibit cell growth. Additionally, in all four GPR30-positive breast cancer lines, ca...Continue Reading
References
Jan 21, 2006·Cancer Research·Charles E WoodJ Mark Cline
Mar 3, 2006·The Journal of Clinical Investigation·Bonnie J Deroo, Kenneth S Korach
Sep 13, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Chang Sun HwangKi Ok Han
Oct 21, 2010·Endocrine·Dengfeng WangChen Chen
Oct 28, 2010·Cancer Research·Pedro de Souza Rocha SimoniniYasser Riazalhosseini
Nov 3, 2010·Journal of Experimental & Clinical Cancer Research : CR·Wen-zhong WangJian-xin Gu
Aug 5, 2011·Environmental Health Perspectives·Zhi-Guo Sheng, Ben-Zhan Zhu
Feb 1, 2012·Breast Cancer Research and Treatment·Rainer GirgertCarsten Gründker
Mar 15, 2012·Current Cancer Drug Targets·R LappanoM Maggiolini
May 5, 2012·Journal of Experimental & Clinical Cancer Research : CR·Zhinong JiangLinbo Wang
Mar 29, 2013·Cancer Research·Kristen N StevensFergus J Couch
Apr 24, 2013·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J TianJ Chen
Feb 21, 2014·Journal of Cancer Research and Clinical Oncology·Christine WeißenbornAtanas Ignatov
Mar 13, 2014·Current Pharmaceutical Design·Pilar RocaJordi Oliver
Mar 13, 2014·PloS One·Jian ChenJing Tian
Mar 29, 2014·Molecular Nutrition & Food Research·Juan E AndradeWilliam G Helferich
Apr 11, 2014·Hormones & Cancer·Allison L ScalingHelen J Hathaway
May 17, 2014·Frontiers in Endocrinology·Rosamaria LappanoMarcello Maggiolini
May 31, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Tenghua YuGang Tu
Aug 28, 2014·European Journal of Pharmacology·Alexander V Sirotkin, Abdel Halim Harrath
Sep 27, 2014·International Journal of Molecular Sciences·Chen WangJi-Min Cao
Oct 11, 2014·World Journal of Clinical Oncology·Iqra BilalSaffron Whitehead
Aug 9, 2015·Toxicology Letters·Anna Maria Wróbel, Ewa Łucja Gregoraszczuk
Oct 30, 2015·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Nov 26, 2015·Food Chemistry·Maria RussoSeyed Mohammad Nabavi
Dec 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alina UifăleanCristina Adela Iuga
Feb 7, 2016·Steroids·Kewen ZhouTinghuai Wang
Mar 13, 2016·Hormones & Cancer·Cameron P CapperRichard J Auchus
May 20, 2016·Cancer Research·Elisa LatorreAlessandro Provenzani
May 24, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giovanni LavorgnaMatteo Bellone
Jun 25, 2016·Molecular Carcinogenesis·Assunta PisanoRosamaria Lappano
Oct 21, 2016·Cancer Research·James N IngleLiewei Wang
Nov 4, 2016·International Journal of Environmental Research and Public Health·Lauren C HoughtonRebecca Troisi
Jan 21, 2017·Cancer Treatment Reviews·Ricardo CostaFrancis J Giles
Mar 7, 2017·Cancer·Omer Kucuk
Apr 13, 2017·Drugs·Rosamaria Lappano, Marcello Maggiolini
Citations
Jun 5, 2019·Journal of Cellular and Molecular Medicine·Rong LiXiaoxi Zhang
Aug 24, 2019·Journal of Experimental & Clinical Cancer Research : CR·Chenlong WangJing Yang
Apr 12, 2019·Combinatorial Chemistry & High Throughput Screening·Xiang LiuYing Zhang
Jan 23, 2020·Nutrients·Małgorzata Zakłos-Szyda, Grażyna Budryn
Feb 23, 2020·BioFactors·Xiaoyu ChenJian Qin
Jun 9, 2019·Journal of Experimental & Clinical Cancer Research : CR·Qun WangLi Lu
Mar 12, 2020·Journal of Applied Microbiology·X LiuJ Wang
Nov 22, 2019·Frontiers in Endocrinology·Prathibha RanganathanSughosha Nambiar
Mar 20, 2020·Molecular Cancer·Francesca CrudeleStefano Volinia
Jun 17, 2020·Immunopharmacology and Immunotoxicology·Yuan LiYanyun Wang
Jul 2, 2020·OncoTargets and Therapy·Qinghua YouHongbo Zhu
Mar 30, 2018·Food & Function·Fang HanXiaodong Sun
Dec 14, 2018·Clinical Science·Luis MolinaPamela Ehrenfeld
Jul 12, 2020·Cell Death & Disease·Yifan LianHongzhi Xu
Jan 5, 2018·Journal of Experimental & Clinical Cancer Research : CR·Jing TianJian Chen
Dec 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Jia LiuShao-Qing Cai
Nov 27, 2020·International Journal of Molecular Sciences·Eleonora A BragaNikolay E Kushlinskii
Jan 12, 2021·Critical Reviews in Food Science and Nutrition·Yang JiangDapeng Li
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Min XinYanhong Guo
Apr 4, 2021·Cancers·Mohammad Reza KalhoriAnupam Bishayee
Apr 13, 2021·Stress : the International Journal on the Biology of Stress·Chad D ForadoriRobert J Kemppainen
Apr 16, 2021·International Immunopharmacology·Gaoyan ChenDongchi Zhao
Apr 16, 2021·Frontiers in Genetics·Xin GuanZhimin Fan
Sep 25, 2020·Journal of Ethnopharmacology·Weiyuan YuanMin Hong
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Guowei GongZhen Wen
Jul 3, 2021·International Journal of Molecular Sciences·Elena A FilippovaEleonora A Braga
Jul 3, 2021·Biomedicines·Mihaela Raluca RaduViorica Elena Rădoi
Jun 8, 2021·Aging·Zhenxia ZhangYuzhong Zheng
May 18, 2021·Molecular and Cellular Biochemistry·Yao Tang, Xiusheng He
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lingping KongAnzhou Tang
Jul 4, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhengzhao LiJianfeng Zhang
Jun 12, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ran MaFulai Wang