Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract

Journal of Ethnopharmacology
Amy Guo-wei GongKarl Wah-Keung Tsim

Abstract

Danggui Buxue Tang (DBT) is a classical Chinese herbal decoction containing two herbs, Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), which serves as dietary supplement for treating women menopausal syndromes. Pharmacological studies indicate that DBT has estrogenic, erythropoietic and osteogenic properties; however, the action mechanism for this complex herbal decoction is not known. Calycosin, a major flavonoid in AR, shares similar structure with β-estradiol, and thus which is hypothesized to be the critical compound of DBT. Here, we aim to investigate the role of calycosin in DBT in terms of its biological functions by using a calycosin-depleted DBT decoction (DBT(Δcal)). The biological functions of DBT(Δcal) and parental DBT were systematically compared. In order to standardize DBT decoction, four chemical markers were determined and quantified by HPLC. A semi-preparative HPLC method was utilized to prepare DBT(Δcal). The authenticity of DBT(Δcal) was evaluated by LC-QQQ-MS/MS. To reveal the effect of calycosin on DBT functions, several cell assays related to the known properties of DBT were revealed, including estrogenic, erythropoietic and osteogenic functions. As compared to parental DBT, the estrogenic, eryth...Continue Reading

References

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Citations

Dec 23, 2015·International Journal of Molecular Sciences·Gui-Hua QuanWan-Chun Sun
Sep 28, 2017·The American Journal of Chinese Medicine·Ryoiti Kiyama
Jan 4, 2020·Combinatorial Chemistry & High Throughput Screening·Jia LiJiajun Chen
Dec 22, 2020·Expert Review of Anti-infective Therapy·Mao DengXiaofang Li
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Guowei GongZhen Wen
Jun 10, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kenneth Kin Leung KwanKarl Wah Keung Tsim

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