Camillo Golgi and Santiago Ramon y Cajal: the anatomical organization of the cortex of the cerebellum. Can the neuron doctrine still support our actual knowledge on the cerebellar structural arrangement?

Brain Research Reviews
C Sotelo

Abstract

Camillo Golgi and Santiago Ramón y Cajal were the two main investigators that revealed the morphological organization of the cerebellar cortex, although they never shared the same basic concepts. While for Golgi all axons fused into a large syncytium (the diffuse nerve network), for Cajal they had free endings and communication between neurons was done by contiguity not by continuity. The classical diagrammatic representation of the cerebellar circuitry shown by Cajal in his Croonian lecture (1894), although still valid, has drastically change by the accumulation of the great amount of data generated from 1894 to our days. The topic of this review is to briefly summarize this new knowledge, and to confront it with Cajal's concepts, to determine whether or not the added complexity to the circuit invalidates the Cajal's principles. Our conclusion is that although most of these principles are consolidated, the applicability of the law of dynamic polarization does not adapt to some of them.

References

Nov 2, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MarianiC Sotelo
Nov 30, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C Sotelo, A Beaudet
Aug 15, 1975·The Journal of Comparative Neurology·E Mugnaini, A L Dahl
Aug 31, 1977·Experimental Brain Research·J Altman, S A Bayer
Mar 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C Sotelo, M Wassef
Nov 22, 1990·The Journal of Comparative Neurology·M Sahin, S Hockfield
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P Mobley, P Greengard
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C Sotelo, R M Alvarado-Mallart
Feb 1, 1969·The Journal of General Physiology·A A Auerbach, M V Bennett
Jan 1, 1971·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·V Chan-Palay, S L Palay
May 1, 1972·The Journal of Cell Biology·C Sotelo, R Llinás
May 1, 1974·The Journal of Comparative Neurology·V M PickelF E Bloom
Jul 14, 1966·Annals of the New York Academy of Sciences·W R Loewenstein
Aug 19, 1969·Experimental Brain Research·T Hökfelt, K Fuxe
Jan 1, 1966·Experimental Neurology·W RallM W Brightman
Jan 1, 1966·Experimental Brain Research·J C EcclesK Sasaki
Jun 1, 1967·The Journal of Cell Biology·J P Revel, M J Karnovsky
Oct 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H Korn, H Axelrad
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J Hámori, J Somogyi

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Citations

Sep 12, 2013·Cell and Tissue Research·Elmira Anderzhanova, Carsten T Wotjak
Jan 25, 2012·Hippocampus·Imre SzirmaiAnita Kamondi
Aug 17, 2018·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Vikramjeet AroraSumit Chawla
May 3, 2021·Trends in Neurosciences·Mark B Stoessel, Ania K Majewska

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