Camouflaging bacteria by wrapping with cell membranes

Nature Communications
Zhenping CaoJinyao Liu

Abstract

Bacteria have been extensively utilized for bioimaging, diagnosis and therapy given their unique characteristics including genetic manipulation, rapid proliferation and disease site targeting specificity. However, clinical translation of bacteria for these applications has been largely restricted by their unavoidable side effects and low treatment efficacies. Engineered bacteria for biomedical applications ideally need to generate only a low inflammatory response, show slow elimination by macrophages, low accumulation in normal organs, and almost unchanged inherent bioactivities. Here we describe a set of stealth bacteria, cell membrane coated bacteria (CMCB), meeting these requirement. Our findings are supported by evaluation in multiple mice models and ultimately demonstrate the potential of CMCB to serve as efficient tumor imaging agents. Stealth bacteria wrapped up with cell membranes have the potential for a myriad of bacterial-mediated biomedical applications.

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Citations

Dec 21, 2019·Biotechnology Journal·Austin G RottinghausTae Seok Moon
Jan 17, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kecan LinMing Wu
Jul 21, 2020·Advanced Materials·Pingping FengJinyao Liu
Jul 9, 2020·Science Advances·Xinyue WangJinyao Liu
Oct 6, 2020·Advanced Biosystems·Järvi M Spanjers, Brigitte Städler
Dec 18, 2020·Advanced Healthcare Materials·Junhee ChoiHongsoo Choi
Mar 11, 2021·Biomaterials Science·Peng LiuWenhu Zhou
Jul 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zhengwei LiuXiaogang Qu
Jul 31, 2021·Nature Biomedical Engineering·Tiffany ChienTal Danino
Jul 28, 2021·Biomaterials Science·Meiyang YangJinghua Chen
Oct 5, 2021·Chemical Society Reviews·Qi-Wen ChenXian-Zheng Zhang
Oct 13, 2021·ACS Biomaterials Science & Engineering·Gaoqian ZhaoHuifang Liu
Oct 30, 2021·Advanced Science·Juanjuan LiJinyao Liu
Dec 4, 2021·ACS Nano·Franco CenturionKourosh Kalantar-Zadeh

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Methods Mentioned

BETA
confocal microscopy
flow cytometry
enzyme-linked immunosorbent assay
ELISA
confocal
transmission electron microscopy

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