cAMP-adenosine pathway in the proximal tubule

The Journal of Pharmacology and Experimental Therapeutics
Edwin K JacksonR K Dubey

Abstract

The "extracellular cAMP-adenosine pathway" refers to the conversion of cAMP to AMP by ecto-phosphodiesterase, followed by metabolism of AMP to adenosine by ecto-5'-nucleotidase, with all the steps occurring in the extracellular compartment. This study investigated whether the extracellular cAMP-adenosine pathway exists in proximal tubules. Freshly isolated proximal tubules rapidly converted basolaterally administered cAMP to AMP and adenosine. Proximal tubular cells in culture (first passage) rapidly converted apically administered cAMP to AMP and adenosine. In both freshly isolated proximal tubules and cultured proximal tubular cells, conversion of cAMP to AMP and adenosine was affected by a broad-spectrum phosphodiesterase inhibitor (3-isobutyl-1-methylxanthine), an ecto-phosphodiesterase inhibitor (1,3-dipropyl-8-p-sulfophenylxanthine), and a blocker of ecto-5'-nucleotidase (alpha,beta-methyleneadenosine-5'-diphosphate) in a manner consistent with exogenous cAMP being processed by the extracellular cAMP-adenosine pathway. In cultured proximal tubular cells, but not freshly isolated proximal tubules, stimulation of adenylyl cyclase increased extracellular concentrations of cAMP, AMP, and adenosine plus inosine, and these chan...Continue Reading

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Citations

Mar 11, 2008·Cancer Immunology, Immunotherapy : CII·Yunyun SuElieser Gorelik
Jul 20, 2007·Molecular and Cellular Biochemistry·Carlos Martínez-SalgadoJosé M López-Novoa
Apr 29, 2008·Purinergic Signalling·Michael B HovaterErik M Schwiebert
Oct 6, 2009·The Journal of Biological Chemistry·Edwin K JacksonZaichuan Mi
Aug 2, 2011·The Journal of Biological Chemistry·Eldo V KuzhikandathilYing Li
Jul 29, 2008·Current Opinion in Nephrology and Hypertension·Francesca Di Sole
Aug 13, 2009·Clinical and Experimental Pharmacology & Physiology·Dongmei ChengEdwin K Jackson
Nov 27, 2008·The Journal of Pharmacology and Experimental Therapeutics·Jin RenEdwin K Jackson
Jun 10, 2011·American Journal of Physiology. Renal Physiology·Edwin K JacksonZaichuan Mi
Sep 3, 2010·American Journal of Physiology. Renal Physiology·Tracy D BellWilliam J Welch
Jul 14, 2012·American Journal of Physiology. Renal Physiology·Edwin K Jackson, Delbert G Gillespie
Sep 23, 2011·American Journal of Physiology. Renal Physiology·Edwin K Jackson
Oct 19, 2012·American Journal of Physiology. Renal Physiology·Edwin K Jackson, Delbert G Gillespie
Jan 19, 2013·Biochimica Et Biophysica Acta·Yisheng ZhongXunda Luo
May 27, 2015·Journal of Cellular Physiology·Victor BabichFrancesca Di Sole
Mar 5, 2008·Gastroenterology·Maria Cecilia GironRosa Maria Gaion
Nov 13, 2009·British Journal of Pharmacology·Katalin MódisCsaba Szabó
Feb 12, 2008·British Journal of Pharmacology·A Gödecke
Jul 23, 2011·Journal of Neurochemistry·Jonathan D VerrierEdwin K Jackson
Sep 4, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Shady M EldaifJakob Vinten-Johansen
Jan 27, 2016·Journal of Neurochemistry·Edwin K JacksonPatrick M Kochanek
Oct 8, 2014·Acta Physiologica·M M Rabadi, H T Lee
Jan 12, 2019·Journal of Cellular Physiology·Victor BabichFrancesca Di Sole
Oct 10, 2006·The Journal of Pharmacology and Experimental Therapeutics·Edwin K JacksonRaghvendra K Dubey
Jan 29, 2008·The Journal of Pharmacology and Experimental Therapeutics·Edwin K Jackson, Zaichuan Mi
Mar 7, 2008·The Journal of Pharmacology and Experimental Therapeutics·Jin RenEdwin K Jackson
Feb 20, 2007·The Journal of Pharmacology and Experimental Therapeutics·Edwin K JacksonZaichuan Mi
Feb 23, 2007·The Journal of Pharmacology and Experimental Therapeutics·Edwin K JacksonRaghvendra K Dubey
May 9, 2014·American Journal of Physiology. Renal Physiology·Edwin K JacksonPatrick M Kochanek

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