cAMP-dependent facilitation of glutamate release by beta-adrenergic receptors in cerebrocortical nerve terminals.

The Journal of Biological Chemistry
I Herrero, J Sánchez-Prieto

Abstract

We have investigated the presence of a cAMP-protein kinase A-dependent pathway in cerebrocortical nerve terminals and its role in the modulation of glutamate release. The activation of adenylyl cyclase with forskolin enhances intrasynaptosomal cAMP and induces Ca2+-dependent glutamate release. The membrane permeant analogue dibutyryl cAMP mimics this facilitatory effect, whereas the inactive compound 1,9-dideoxyforskolin is without effect. This cAMP-induced facilitation is consistent with the induction of spontaneous action potentials that are abolished by the Na+ channel blocker tetrodotoxin and by reducing nerve terminal excitability with arachidonic acid. We have also demonstrated that a beta-adrenergic receptor is linked to this pathway because isoproterenol increases cAMP levels and glutamate release, and both actions are antagonized by the receptor antagonist propanolol and the protein kinase A inhibitors H89 and 8-chloroadenosine 3',5'-monophosphorothioate ((Rp)-isomer). The finding that the increase in cytoplasmic free Ca2+ concentration induced by synaptic activity reduces the concentration of agonist required to maximally activate adenylyl cyclase suggests that this enzyme may act as a coincidence detector, integratin...Continue Reading

References

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Citations

Jan 8, 2005·The Journal of Membrane Biology·C FauserP Wangemann
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Elzbieta LuchowskaEwa M Urbańska
Jun 28, 2000·Journal of the Autonomic Nervous System·M T Miras-PortugalJ Pintor
Sep 9, 2009·Cephalalgia : an International Journal of Headache·C Ayata
Feb 24, 2010·Indian Journal of Pharmacology·Radha GoelRashmi S Srivastava
Oct 20, 2007·Journal of Neurochemistry·Carolina LaderaJosé Sánchez-Prieto
Apr 27, 2017·Journal of Neurochemistry·Beatris AlonsoJosé Sánchez-Prieto
Nov 19, 2003·Journal of Neurochemistry·Carmelo MillánJosé Sánchez-Prieto
Aug 9, 2003·Journal of Neurophysiology·Nelson RebolaRodrigo A Cunha
Jul 23, 2014·The Journal of Pharmacology and Experimental Therapeutics·Tzu-Yu LinSu-Jane Wang
Feb 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiali YinHaojun Luo
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R A SantizoD A Pelligrino
May 29, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cheng Wei LuSu Jane Wang

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