cAMP-dependent oncogenic action of Rap1b in the thyroid gland.

The Journal of Biological Chemistry
Fernando Ribeiro-NetoDaniel L Altschuler

Abstract

cAMP signaling leads to activation and phosphorylation of Rap1b. Using cellular models where cAMP stimulates cell proliferation, we have demonstrated that cAMP-mediated activation, as well as phosphorylation of Rap1b, is critical for cAMP stimulation of DNA synthesis. To determine whether Rap1b stimulates mitogenesis in vivo, we have constructed a transgenic mouse where a constitutively active G12V-Rap1b, flanked by Cre recombinase LoxP sites, is followed by the dominant negative S17N mutant. Employing this novel mouse model, we have switched, in a tissue-specific (thyroid) and temporally controlled manner, the expression of Rap1b from a stimulatory to an inhibitory form. These experiments provide conclusive evidence that Rap1b is oncogenic in the thyroid in ways linked to transduction of the cAMP mitogenic signal.

References

Jan 1, 1975·Annual Review of Biochemistry·I H PastanW B Anderson
Feb 1, 1991·British Journal of Cancer·G A ThomasE D Williams
Aug 1, 1972·The Journal of Clinical Investigation·P J Snyder, R D Utiger
Jul 7, 1995·The Journal of Biological Chemistry·R WieneckeJ E DeClue
May 5, 1995·The Journal of Biological Chemistry·D L AltschulerE G Lapetina
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·F M MichielsJ Feunteun
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·C LedentM Parmentier
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·J BrocardD Metzger
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·D L Altschuler, F Ribeiro-Neto
Dec 18, 1998·Science·H KawasakiA M Graybiel
Dec 2, 1999·Experimental Cell Research·F J Zwartkruis, J L Bos
Jan 12, 2001·Physiological Reviews·Y TakaiT Matozaki
Mar 30, 2001·The Journal of Biological Chemistry·A J DupuyD A Largaespada
May 8, 2001·Molecular and Cellular Biology·J M Schmitt, P J Stork
Jun 28, 2001·Physiological Reviews·P M Yen
Jan 24, 2002·Molecular Cell·John M Schmitt, Philip J S Stork
Feb 16, 2002·Science·Andrea L Knox, Nicholas H Brown
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Fernando Ribeiro-NetoDaniel L Altschuler
Jul 10, 2002·Progress in Nucleic Acid Research and Molecular Biology·Lawrence A QuilliamAriel F Castro
Aug 3, 2002·Nature Reviews. Cancer·Ann F ChambersIan C MacDonald
Dec 20, 2002·Thyroid : Official Journal of the American Thyroid Association·Hideyo SuzukiSheue-Yann Cheng
Dec 21, 2002·Differentiation; Research in Biological Diversity·Isaiah J Fidler
Jan 28, 2003·Biochemical Society Transactions·J L BosF Zwartkruis
Feb 13, 2003·Annals of the New York Academy of Sciences·Lydia Jiménez-DíazJosé M Delgado-García
Mar 12, 2003·Cell·Vijay YajnikDaniel A Haber
Mar 15, 2003·Nature Reviews. Cancer·John D Hood, David A Cheresh
Apr 1, 2003·Endocrine Pathology·Giovanni Tallini
Apr 4, 2003·Glia·Anthony J ApicelliDavid H Gutmann
Jun 5, 2003·The Journal of Biological Chemistry·Daniel HochbaumOmar A Coso
Jun 24, 2003·Nature Cell Biology·Marjorie MailletFrank Lezoualc'h
Aug 2, 2003·Cancer Cell·David A Largaespada
Oct 23, 2003·Nature Reviews. Molecular Cell Biology·Kayoko KinbaraMark H Ginsberg

❮ Previous
Next ❯

Citations

Apr 10, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·X-G Zhu, S-Y Cheng
Nov 5, 2010·The Journal of Biological Chemistry·Daniel HochbaumDaniel L Altschuler
Jun 14, 2008·The Journal of Biological Chemistry·Kyoungja HongDaniel L Altschuler
Oct 8, 2011·Omics : a Journal of Integrative Biology·Dan LiGui-Yuan Li
Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Thomas KlonischSabine Hombach-Klonisch
Dec 17, 2009·Thyroid : Official Journal of the American Thyroid Association·Caroline S Kim, Xuguang Zhu
Jul 25, 2007·Molecular and Cellular Biology·Oxana M TsygankovaJudy L Meinkoth
Dec 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Anoma NelloreMarcia S Brose
Oct 25, 2008·Endocrine Journal·Michiko MatsuseShunichi Yamashita
Jan 14, 2012·Experimental Cell Research·Wilma C G van StaverenCarine Maenhaut
Jul 1, 2015·Molecular and Cellular Endocrinology·Lawrence S KirschnerAmruta Ashtekar
Jan 27, 2006·The American Journal of Pathology·Zhaocheng ZhangNisha J D'Silva
Jul 7, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Minjing ZouYufei Shi
Jan 2, 2007·Veterinary Pathology·K A B KnostmanC C Capen
Apr 6, 2018·The Journal of Biological Chemistry·Xuefeng ZhangDaniel L Altschuler
Jun 9, 2018·Thyroid : Official Journal of the American Thyroid Association·Danielle J HukLawrence S Kirschner
Sep 6, 2007·Journal of Cellular Physiology·Enrique Rozengurt
Nov 27, 2018·The Journal of Endocrinology·Manuel D GaheteRaul M Luque
Dec 8, 2007·The Journal of Biological Chemistry·Daniel HochbaumDaniel L Altschuler
Jan 1, 2018·Hormones and Behavior·Kathryn L G RussartLawrence S Kirschner
Jun 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Xuefeng ZhangDaniel L Altschuler
Aug 8, 2021·Cancers·Georgia PitsavaFabio R Faucz

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Fernando Ribeiro-NetoDaniel L Altschuler
The Journal of Biological Chemistry
Judith H Raaijmakers, Johannes L Bos
Nature Reviews. Molecular Cell Biology
Johannes L BosK A Reedquist
Annual Review of Pharmacology and Toxicology
Martijn Gloerich, Johannes L Bos
© 2021 Meta ULC. All rights reserved