cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Kacper A WojtalSven C D Van IJzendoorn

Abstract

Cyclic adenosine monophosphate (cAMP) and cAMP-dependent protein kinase A (PKA) are evolutionary conserved molecules with a well-established position in the complex network of signal transduction pathways. cAMP/PKA-mediated signaling pathways are implicated in many biological processes that cooperate in organ development including the motility, survival, proliferation and differentiation of epithelial cells. Cell surface polarity, here defined as the anisotropic organisation of cellular membranes, is a critical parameter for most of these processes. Changes in the activity of cAMP/PKA elicit a variety of effects on intracellular membrane dynamics, including membrane sorting and trafficking. One of the most intriguing aspects of cAMP/PKA signaling is its evolutionary conserved abundance on the one hand and its precise spatial-temporal actions on the other. Here, we review recent developments with regard to the role of cAMP/PKA in the regulation of intracellular membrane trafficking in relation to the dynamics of epithelial surface domains.

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Citations

May 26, 2009·The Journal of Biological Chemistry·Kacper A WojtalSven C D van Ijzendoorn
Jun 18, 2010·Molecular Biology of the Cell·Andrés NorambuenaAlfonso González
Jun 27, 2008·Journal of Virology·Michelle J FarquharJane A McKeating
Nov 1, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian D FingasGregory J Gores
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·Juliana L DreyfussHelena B Nader
Mar 15, 2014·International Journal of Molecular Medicine·Longzhen PiaoJongsun Park
Jun 14, 2020·Nature Communications·Lia DominguesCédric Delevoye
Apr 15, 2010·Science Signaling·Ljiljana Milenkovic, Matthew P Scott

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