cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy

Advances in Protein Chemistry and Structural Biology
Nathaniel C HolcombJohn August D'Orazio

Abstract

Malignant melanoma of the skin is the leading cause of death from skin cancer and ranks fifth in cancer incidence among all cancers in the United States. While melanoma mortality has remained steady for the past several decades, melanoma incidence has been increasing, particularly among fair-skinned individuals. According to the American Cancer Society, nearly 10,000 people in the United States will die from melanoma this year. Individuals with dark skin complexion are protected damage generated by UV-light due to the high content of UV-blocking melanin pigment in their epidermis as well as better capacity for melanocytes to cope with UV damage. There is now ample evidence that suggests that the melanocortin 1 receptor (MC1R) is a major melanoma risk factor. Inherited loss-of-function mutations in MC1R are common in melanoma-prone persons, correlating with a less melanized skin complexion and poorer recovery from mutagenic photodamage. We and others are interested in the MC1R signaling pathway in melanocytes, its mechanisms of enhancing genomic stability and pharmacologic opportunities to reduce melanoma risk based on those insights. In this chapter, we review melanoma risk factors, the MC1R signaling pathway, and the relations...Continue Reading

Citations

Aug 11, 2020·Pigment Cell & Melanoma Research·Jakyung Bang, Jonathan H Zippin
Dec 29, 2020·Cancer Letters·Jiajia ZhangChen Wu
Dec 18, 2019·Colloids and Surfaces. B, Biointerfaces·Salima El Yakhlifi, Vincent Ball
Aug 8, 2021·Journal of Clinical Medicine·Lionel Larribère, Jochen Utikal

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