cAMP signalling in Trypanosoma brucei

International Journal for Parasitology
T SeebeckR Zoraghi

Abstract

Cyclic AMP was the first second messenger to be identified. After five decades of research, much is currently known about its biological functions and clinical implications. Several components of the cAMP signalling pathways, such as the G-protein coupled receptors and the phosphodiesterases, have become sensitive and specific drug targets for a host of clinical applications. Surprisingly, very little effort has been invested so far into the study of cAMP signalling in parasites, and its significance in host/parasite interaction. Our laboratory has embarked on a study of cAMP signalling in Trypanosoma brucei. A newly identified adenylyl cyclase, GRESAG4.4B, a member of a small family of closely related genes, is being used as a model molecule for investigating the mechanisms which control cyclase activity in the T. brucei cell. On the other hand, a number of genes for different families of cAMP-specific phosphodiesterases have been identified and characterised. One enzyme, TbPDE1, is coded for by a single-copy gene. Knock-outs of this gene display an almost normal phenotype in culture, indicating that TbPDE1 is not an essential enzyme under culture conditions. A second phosphodiesterase which is being studied in detail, TbPDE2A...Continue Reading

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P SassM Wigler
Nov 1, 1987·Journal of General Microbiology·E LesuisseR R Crichton
Apr 1, 1974·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R D WalterE Königk
Nov 1, 1974·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R D Walter
Jul 21, 1995·The Journal of Biological Chemistry·M A SanchezS M Landfear
Jan 1, 1996·Annual Review of Pharmacology and Toxicology·R K SunaharaA G Gilman
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·S YuD L Garbers
Jan 20, 1998·Trends in Biochemical Sciences·L Aravind, C P Ponting
Apr 21, 1998·Advances in Pharmacology·D SpinaC P Page
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·J BuckL R Levin
Jul 10, 1999·Drugs·H D Langtry, A Markham
Jul 27, 1999·Current Opinion in Chemical Biology·A M Doherty
Jul 31, 1999·Science·J J TesmerS R Sprang
Dec 3, 1999·Methods : a Companion to Methods in Enzymology·D L Garbers
Dec 11, 1999·Molecular and Biochemical Parasitology·M C TaylorJ M Kelly
Jan 5, 2000·Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques·M S Barnette
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B BielekovaR Martin
Jan 19, 2000·Parasitology Today·C Naula, T Seebeck
Mar 14, 2000·Acta Crystallographica. Section D, Biological Crystallography·B Bieger, L O Essen

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Citations

Mar 21, 2002·Il Farmaco·Piaz Vittorio DalM C Castellana
Dec 6, 2001·European Journal of Biochemistry·T ShalabyT Seebeck
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ana RascónJoseph A Beavo
Dec 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sunil LaxmanJoseph A Beavo
Apr 24, 2002·Antioxidants & Redox Signaling·Daniel J Steenkamp
Feb 1, 2012·The Journal of Infectious Diseases·Harry P de KoningThomas Seebeck
Aug 13, 2003·Eukaryotic Cell·Martin WieseChristoph G Grünfelder
Jul 8, 2003·Kinetoplastid Biology and Disease·John Richard Seed, Mary Anne Wenck
Oct 5, 2015·Trends in Parasitology·Simon Imhof, Isabel Roditi
Sep 24, 2004·Molecular and Biochemical Parasitology·Jesse Frederick, Dan Eichinger
Jan 13, 2011·FEMS Microbiology Reviews·Matthew K Gould, Harry P de Koning
Jan 16, 2007·Molecular and Biochemical Parasitology·Guillermo D AlonsoMirtha M Flawiá
Sep 17, 2014·Molecular & Cellular Proteomics : MCP·Rayner M L QueirozCarlos A O Ricart
Jul 5, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ifedayo Victor Ogungbe, William N Setzer
Jun 12, 2009·Critical Reviews in Microbiology·Irina V Shemarova
Jan 27, 2004·Molecular Pharmacology·Roya ZoraghiSharron H Francis
Jun 21, 2019·Current Medicinal Chemistry·Alejandra Cecilia SchoijetGuillermo Daniel Alonso
Jan 20, 2004·European Journal of Biochemistry·Stefan KunzMichael Boshart

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African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.