Campest-5-en-3-one, an oxidized derivative of campesterol, activates PPARalpha, promotes energy consumption and reduces visceral fat deposition in rats

Biochimica Et Biophysica Acta
Ikuo IkedaK Suzuki

Abstract

Dietary campest-5-en-3-one (campestenone), an oxidized derivative of campesterol, significantly reduced visceral fat weight and the concentration of triacylglycerol in serum and liver of rats. Dietary campestenone dramatically increased the activities and the mRNA expressions of mitochondrial and peroxisomal enzymes involved in beta-oxidation in the liver. Campestenone activated human peroxisome proliferator-activated receptor (PPAR) alpha as determined using the novel GAL4 ligand-binding domain chimera assay system with coactivator coexpression. In contrast, dietary campestenone reduced the activities and the mRNA expressions of enzymes involved in fatty acid synthesis, except for the malic enzyme. Dietary campestenone decreased the sterol regulatory element binding protein-1 (SREBP-1) mRNA level. Energy expenditure was significantly higher in the feeding of campestenone in rats. Dietary campestenone reduced hepatic cholesterol concentration and increased fecal excretion of neutral steroids originated from cholesterol. Lymphatic absorption of cholesterol was reduced by the coadministration of campestenone in rats cannulated in the thoracic duct. These observations suggest a possibility that campestenone has an ability to preve...Continue Reading

Citations

Feb 5, 2013·Lipids in Health and Disease·Koji NagaoTeruyoshi Yanagita
Jul 19, 2008·Journal of Nutritional Science and Vitaminology·Makoto KobayashiIkuo Ikeda
Apr 22, 2015·Obesity Research & Clinical Practice·Satoshi WanezakiMitsutaka Kohno
Sep 12, 2014·Bioscience, Biotechnology, and Biochemistry·Ikuo IkedaMichio Komai
Jan 8, 2008·Progress in Lipid Research·Koji Nagao, Teruyoshi Yanagita
Sep 25, 2016·Plant Foods for Human Nutrition·Rong ShuangLi Wenfang
Jul 3, 2007·Phytotherapy Research : PTR·Jung-Min ChoiSung-Hoon Kim
Nov 21, 2007·Progress in Lipid Research·Egbert HovenkampElke A Trautwein
Sep 28, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Otaegui-ArrazolaI Astiasarán
Jun 28, 2011·Chemistry and Physics of Lipids·Guadalupe García-Llatas, María Teresa Rodríguez-Estrada

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