CAMPHOR score: patient-reported outcomes are improved by pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension.

The European Respiratory Journal
Michael NewnhamJoanna Pepke-Zaba

Abstract

Pulmonary endarterectomy (PEA) is the recommended treatment for eligible patients with chronic thromboembolic pulmonary hypertension (CTEPH). The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) score is an internationally validated patient-reported outcome (PRO) measure for CTEPH. It assesses three domains: activity, quality of life (QoL) and symptoms. We assessed PROs in patients with CTEPH undergoing PEA. This retrospective observational study of consecutive CTEPH patients undergoing PEA at the UK national PEA centre between 2006 and 2017 assessed change in CAMPHOR score from baseline (pre-PEA) until up to 5 years post-PEA. CAMPHOR scores were compared between 1) those with and without clinically significant residual pulmonary hypertension and 2) those undergoing PEA and propensity-matched CTEPH patients who were not operated on. The minimally clinically important difference (MCID) was calculated using an anchor-based method. Out of 1324 CTEPH patients who underwent PEA, 1053 (80%) had a CAMPHOR score recorded pre-PEA, 934 (71%) had a score recorded within a year of PEA and 784 (60%) had both. There were significant improvements between pre- and post-PEA in all three CAMPHOR domains (median±interquartile range activ...Continue Reading

References

Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·C J ArchibaldK M Moser
Nov 26, 2002·The Journal of Thoracic and Cardiovascular Surgery·Patricia A ThistlethwaiteStuart W Jamieson
Jan 18, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·S P McKennaJ Pepke-Zaba
May 27, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Seishi YoshimiTakayuki Kuriyama
May 18, 2010·The Journal of Thoracic and Cardiovascular Surgery·Darren H FreedDavid P Jenkins
Jun 23, 2012·American Journal of Respiratory and Critical Care Medicine·Stephen C MathaiRobert A Wise
Jul 13, 2013·BMC Pulmonary Medicine·James TwissEli Gabbay
Jul 26, 2013·The New England Journal of Medicine·Hossein-Ardeschir GhofraniUNKNOWN CHEST-1 Study Group
Nov 16, 2013·The European Respiratory Journal·Janelle YorkeIain Armstrong
Sep 23, 2014·The European Respiratory Journal·Dolores TaboadaKaren K Sheares
Apr 15, 2016·The European Respiratory Journal·Stephen C MathaiGérald Simonneau
Jul 16, 2016·Journal of Applied Physiology·Athanasios CharalampopoulosLuke S Howard
Aug 30, 2016·Annals of the American Thoracic Society·Joanna Pepke-ZabaRichard Channick
Mar 17, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·David JenkinsEckhard Mayer
Oct 2, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Oksana KamenskayaAlexander Karaskov
Jul 14, 2018·The European Respiratory Journal·Syed Rehan QuaderyDavid G Kiely
Jul 17, 2018·Respiratory Investigation·Nobuhiro TanabeKoichiro Tatsumi
Nov 10, 2018·International Journal of Cardiology·Aleksander AraszkiewiczMarcin Kurzyna
Dec 14, 2018·The European Respiratory Journal·Nick H KimDavid P Jenkins
Dec 14, 2018·The European Respiratory Journal·Olivier SitbonLewis J Rubin
Dec 14, 2018·The European Respiratory Journal·Michael D McGoonBrad A Wong
Dec 16, 2018·The European Respiratory Journal·Nazzareno GalièGerald Simonneau
Dec 21, 2018·European Journal of Preventive Cardiology·Carla FavocciaKonstantinos Dimopoulos

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