Camptothecin encapsulated into functionalized MCM-41: In vitro release study, cytotoxicity and kinetics

Materials Science & Engineering. C, Materials for Biological Applications
Priyanka SolankiAnjali Patel

Abstract

The application of MCM-41 functionalized by 12-tungstophosphoric acid (TPA) as drug carrier for cancer treatment was studied by loading of camptothecin (CPT). In-vitro controlled release study of CPT in Simulated Body Fluid (pH 7.4, 37 °C) was carried out under stirring as well as static conditions. The systems were also evaluated on cancer cells (HepG2) and the carriers are found to be non-toxic to the cancer cells. In order to see the influence of inorganic moiety on release rate of drug, study was also carried out with CPT loaded unfunctionalized MCM-41. A detailed study on release kinetics and release mechanism using First Order Release Kinetic Model, Higuchi Model, Koresmeyer-Pepps Model and Extended kinetic model was also carried out.

Citations

Nov 7, 2019·Applied Microbiology and Biotechnology·Fábio Gonçalves Macêdo de MedeirosMárcia Regina da Silva Pedrini
Jun 20, 2020·Drug Development and Industrial Pharmacy·Laís F Azevedo de M OliveiraEduardo J da Silva Fonseca

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