Can advanced-stage ovarian cancer be cured?

Nature Reviews. Clinical Oncology
Steven A Narod

Abstract

Approximately 20% of women with advanced-stage ovarian cancer survive beyond 12 years after treatment and are effectively cured. Initial therapy for ovarian cancer comprises surgery and chemotherapy, and is given with the goal of eradicating as many cancer cells as possible. Indeed, the three phases of therapy are as follows: debulking surgery to remove as much of the cancer as possible, preferably to a state of no visible residual disease; chemotherapy to eradicate any microscopic disease that remains present after surgery; and second-line or maintenance therapy, which is given to delay disease progression among patients with tumour recurrence. If no cancer cells remain after initial therapy is completed, a cure is expected. By contrast, if residual cancer cells are present after initial treatment, then disease recurrence is likely. Thus, the probability of cure is contingent on the combination of surgery and chemotherapy effectively eliminating all cancer cells. In this Perspectives article, I present the case that the probability of achieving a cancer-free state is maximized through a combination of maximal debulking surgery and intraperitoneal chemotherapy. I discuss the evidence indicating that by taking this approach, cur...Continue Reading

References

Dec 4, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J EngelD Hölzel
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert F OzolsUNKNOWN Gynecologic Oncology Group
Mar 7, 2006·Cancer·Kenneth R HessJames L Abbruzzese
Nov 20, 2009·Gynecologic Oncology·Heidi J GrayBarbara A Goff
Sep 8, 2010·The New England Journal of Medicine·Ignace VergoteUNKNOWN NCIC Clinical Trials Group
Dec 30, 2011·The New England Journal of Medicine·Robert A BurgerUNKNOWN Gynecologic Oncology Group
Dec 30, 2011·The New England Journal of Medicine·Timothy J PerrenUNKNOWN ICON7 Investigators
Jan 26, 2012·JAMA : the Journal of the American Medical Association·Kelly L BoltonUNKNOWN Cancer Genome Atlas Research Network
Dec 22, 2012·Journal of the National Cancer Institute·John R McLaughlinSteven A Narod
Oct 22, 2013·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MorganUNKNOWN National comprehensive cancer networks
Nov 1, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Pascale AmateFabrice R Lécuru
Mar 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Pujade-LauraineIsabelle Ray-Coquard
Nov 16, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Francisco J Candido-dos-ReisUNKNOWN Australian Ovarian Cancer Study Group
Feb 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil S HorowitzG Larry Maxwell
Feb 25, 2015·Nature Reviews. Clinical Oncology·Alpa M NickAnil K Sood
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Devansu TewariJohn K Chan
May 29, 2015·Nature·Ann-Marie PatchDavid D L Bowtell
Jun 17, 2015·Gynecologic Oncology·Victoria SopikSteven A Narod
Aug 5, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alexi A WrightDavid M O'Malley
Aug 6, 2015·Obstetrics and Gynecology·Rosemary D CressGary S Leiserowitz
Oct 24, 2015·Nature Reviews. Cancer·David D BowtellFrances R Balkwill
Nov 12, 2015·Gynecologic Oncology·Joanne KotsopoulosSteven A Narod
Jul 10, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andrew L LaccettiDavid E Gerber

❮ Previous
Next ❯

Citations

Jun 30, 2016·The New England Journal of Medicine·John K ChanBradley J Monk
Mar 21, 2017·Gynecologic Oncology·Jacob McGeeUNKNOWN Hereditary Ovarian Cancer Clinical Study Group
Apr 26, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taymaa MayPrafull Ghatage
Jan 4, 2017·Gynecologic Oncology·Roy KessousWalter H Gotlieb
Dec 22, 2017·Journal of Cellular Physiology·Maria C PazosGriselda Irusta
Nov 14, 2017·The Journal of Clinical Investigation·Alexia T KedvesWilliam C Forrester
Sep 13, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Vladimir G BespalovAlexey M Belyaev
Jul 4, 2018·Advanced Healthcare Materials·Ji QiBen Zhong Tang
Feb 4, 2019·Radiology and Oncology·Katarina CerneBorut Kobal
May 18, 2019·BMC Medical Research Methodology·Juste Aristide GoungoungaUNKNOWN CENSUR working survival group
Mar 2, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nimisha AroraGillian E Hanley
Jul 28, 2019·Cancers·Laurie G HudsonAngela Wandinger-Ness
Jun 4, 2019·Journal of Cellular Physiology·Gailing LiGuijun Qin
Nov 21, 2019·Angewandte Chemie·Natalie BoehnkePaula T Hammond
Sep 19, 2019·Cell Transplantation·Liangliang HuQinan Yin
Mar 19, 2020·Cancer Biotherapy & Radiopharmaceuticals·Suiyang ZhouXianchao Kong
Dec 30, 2017·Oncology Letters·Zhen HuangBeihua Kong
Mar 1, 2019·International Journal of Molecular Sciences·Michael-Antony LisioCarlos Telleria
Aug 9, 2020·International Journal of Nanomedicine·Barbara BortotStefania Biffi
Jun 27, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Madeline T OlsonAaron M Mohs
May 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taymaa MayPrafull Ghatage
Jun 17, 2020·Cancer Cell International·Yunhe AnFangqi Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Obstetrics and Gynecology
G R Weiss
L'unión médicale du Canada
A de GramontP Ouellet
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Clinical Advances in Hematology & Oncology : H&O
Maurie Markman
© 2022 Meta ULC. All rights reserved