PMID: 9188928Apr 1, 1997Paper

Can an antihistamine delay appearance of hay fever symptoms when given prior to pollen season?

Allergy
M A SternD Tudor

Abstract

Mizolastine is a new, nonsedating antihistamine providing satisfactory symptom relief in allergic conditions. The purpose of this study was to determine whether the onset of hay fever symptoms could be delayed in patients known to suffer seasonal allergic rhinoconjunctivitis symptoms if mizolastine was given before the pollen season. This double-blind study involved 342 patients, randomly allocated to once-daily 10 mg mizolastine (n = 115), once-daily 120 mg terfenadine (n = 116), or placebo (n = 111) groups. All patients started treatment on 1 May, before the onset of the grass pollen season. The prophylactic effect of test drugs was assessed on their ability to delay the time to the first hay fever crisis of the season, which was defined by the occurrence of one of the following events: use of rescue medication, study withdrawal because of treatment failure, or total diary symptom score over 18. Active treatments prolonged the time to the first crisis by approximately 1 week (mizolastine 55 days, terfenadine 57 days) in comparison with placebo (50 days) (survival curve analysis: Logrank test, P = 0.01; Wilcoxon test, P = 0.03). Tolerability was satisfactory and comparable between groups. Thus, mizolastine can be safely used t...Continue Reading

References

Jan 1, 1994·International Clinical Psychopharmacology·A PatatP Rosenzweig
Jul 1, 1993·The Journal of Allergy and Clinical Immunology·G R SoparkarD W Cockcroft
Jan 1, 1997·American Journal of Rhinology·W HosemannA Felderhoff

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Citations

Nov 13, 2008·International Journal of Biometeorology·C A SkjøthJ Emberlin
Mar 5, 2002·British Journal of Clinical Pharmacology·A PurohitN Frossard
Jul 27, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C A SkjøthJ Brandt
Jun 22, 2007·Allergology International : Official Journal of the Japanese Society of Allergology·Yuichi TakahashiMasahiro Sakaguchi
May 21, 1999·British Journal of Clinical Pharmacology·S ChaufourP Rosenzweig
Jul 10, 1999·The Journal of International Medical Research·M SternM S Judd

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