Can anodised zirconium implants stimulate bone formation? Preliminary study in rat model.

Progress in Biomaterials
María R KatunarS Ceré

Abstract

The mechanical properties and good biocompatibility of zirconium and some of its alloys make these materials good candidates for biomedical applications. The attractive in vivo performance of zirconium is mainly due to the presence of a protective oxide layer. In this preliminary study, the surface of pure zirconium modified by anodisation in acidic media at low potentials to enhance its barrier protection given by the oxides and osseointegration. Bare, commercially pure zirconium cylinders were compared to samples anodised at 30 V through electrochemical tests and scanning electron microscopy (SEM). For both conditions, in vivo tests were performed in a rat tibial osteotomy model. The histological features and fluorochrome-labelling changes of newly bone formed around the implants were evaluated on the non-decalcified sections 63 days after surgery. Electrochemical tests and SEM images show that the anodisation treatment increases the barrier effect over the material and the in vivo tests show continuous newly formed bone around the implant with a different amount of osteocytes in their lacunae depending on the region. There was no significant change in bone thickness around either kind of implant but the anodised samples had ...Continue Reading

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Citations

Sep 23, 2020·Journal of Biomedical Materials Research. Part a·Andrea Gomez SanchezSilvia Ceré
Apr 11, 2016·ACS Biomaterials Science & Engineering·Giselle C YeoMarcela M M Bilek

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thermal treatments
scanning electron microscopy
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fluorescence microscopy
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