Can antidepressants prevent interferon-alpha-induced depression? A review of the literature

General Hospital Psychiatry
Amanda Galvão-de AlmeidaLucas C Quarantini

Abstract

To review the literature about the efficacy of antidepressant prophylaxis during interferon-alpha (IFN-alpha) therapy. We have performed a database search in PUBMED and ISI Web of Knowledge (1980-August 2009) for the available literature. The keywords "prevention" or "prophylaxis", and "depression", and "interferon", and "antidepressant" or "antidepressive agents" were used. The six eligible studies comprise three randomized controlled trials, two in hepatitis C virus (HCV) patients and one in individuals with melanoma, and three open-label studies with HCV patients. The results of the randomized controlled trials suggest that antidepressant prophylaxis may blunt the magnitude of depressive symptoms in HCV patients and raise the rates of treatment completion. In melanoma patients, this preventive strategy may reduce the incidence of depression during IFN-alpha treatment. In addition, the open-label studies with HCV patients suggest that this strategy may reduce the onset of major depression in specific samples (current psychiatric diagnosis, major depression in remission, past history of IFN-alpha-induced depression) on IFN-alpha (re-)treatment. In the face of so few trials about the usefulness of prophylaxis with antidepressan...Continue Reading

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Citations

May 8, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hai-Yin JiangBing Ruan
Oct 25, 2011·General Hospital Psychiatry·Mauro García-ToroMiquel Roca
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