Can biomarkers play a role in the decision about treatment of the clinically negative neck in patients with head and neck cancer?

Head & Neck
Robert P TakesAlfio Ferlito

Abstract

For most patients with head and neck squamous cell cancer, a treatment decision concerning the neck is required. Since detection of small metastases in lymph nodes is difficult, many of the patients with no detectable metastases receive elective treatment of the neck. Additional information on the metastatic potential of the primary tumor before treatment may be useful to reduce the number of these elective procedures. Biomarkers may supply such information. Molecules involved in several pathways have been studied, but the complexity of the metastatic process makes it unlikely that a single marker for metastasis can de identified. Techniques allowing the study of many factors simultaneously seem to be the most promising ones. In recent years, microarray expression profiling and comparative genomic hybridization studies have yielded interesting results. If these results can be confirmed in larger studies, they may play a role in future clinical decision making on treatment of the clinically N0 neck.

References

Feb 1, 1992·Scientific American·L A Liotta
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M D SchallerJ T Parsons
Jan 1, 1992·Acta Oto-laryngologica. Supplementum·M Tytor, J Olofsson
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Oct 1, 1994·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D A LeedyJ I Cohen
Nov 1, 1994·American Journal of Surgery·J K WilliamsM J Jurkiewicz
Jul 1, 1995·Head & Neck·U K ZätterströmJ Wennerberg
Jul 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M Y KuoC P Chiang
Feb 16, 1995·The New England Journal of Medicine·J A BrennanD Sidransky
Oct 1, 1993·Current Opinion in Cell Biology·M Takeichi
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·G GaspariniP Bevilacqua
Apr 1, 1996·The British Journal of Surgery·W G Jiang
Aug 1, 1996·Archives of Otolaryngology--head & Neck Surgery·T ShpitzerK Segal
Mar 1, 1997·Acta Oto-laryngologica·J O PulkkinenR Grénman
Apr 1, 1997·Archives of Otolaryngology--head & Neck Surgery·R P TakesJ H van Krieken
Jan 1, 1994·European Journal of Cancer. Part B, Oral Oncology·A S Jones
May 1, 1997·Archives of Otolaryngology--head & Neck Surgery·R J MichalidesA J Balm
Jan 1, 1997·The Journal of Laryngology and Otology·S K SarkerD V Coleman
Jun 30, 1998·International Journal of Cancer. Journal International Du Cancer·G PruneriR Buffa
Aug 1, 1998·Otolaryngologic Clinics of North America·M W van den BrekelG B Snow
Feb 23, 1999·British Journal of Cancer·A AnttonenH Joensuu
Aug 12, 1999·The Laryngoscope·A L Kuntz, E A Weymuller
Nov 5, 1999·The Journal of Pathology·S Curran, G I Murray

❮ Previous
Next ❯

Citations

Nov 19, 2010·Radiation and Environmental Biophysics·Hendrik A WolffHans Christiansen
Feb 21, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alfio FerlitoAlessandra Rinaldo
Jul 24, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Alfio Ferlito, Alessandra Rinaldo
Dec 29, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Magdy E MahfouzAlfio Ferlito
Oct 18, 2008·Journal of the American College of Surgeons·Alfio FerlitoPatrick J Bradley
Jul 9, 2009·European Journal of Oral Sciences·Nasta TanićBogomir Dimitrijević
Jul 27, 2012·Journal of Surgical Oncology·Georgios PsychogiosHeinrich Iro
Mar 2, 2010·Head & Neck·Robert P TakesAlfio Ferlito
Feb 9, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Moni Abraham Kuriakose
Nov 8, 2015·American Journal of Otolaryngology· Ali BayramErcihan Güney
Aug 2, 2011·Oral Oncology·Sabrina Daniela da SilvaLuiz P Kowalski
Jan 27, 2018·Oncotarget·Ioanna GiopanouGeorgios T Stathopoulos
Apr 14, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
S CağliE Güney
Oral Oncology
Eric M GendenCrispian Scully
© 2021 Meta ULC. All rights reserved