PMID: 40705Jul 2, 1979

Can blockade of presynaptic adrenergic beta receptors explain the antihypertensive effects of propranolol?

Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles
J L Montastruc, P Montastruc

Abstract

Pretreatment with 6-hydroxydopamine abolished the antihypertensive effects of intravenously and intracisternally administered dl-propranolol in dogs with acute neurogenic hypertension. These results show that the anti-hypertensive action of this drug is dependant on the integrity of central catecholaminergic neurones and suggest an action on presynaptic bêta-adrenoceptors.

Related Concepts

Diastolic Blood Pressure
Neurons
Hydroxydopamine
Hypertensive Disease
Catecholamines
Rexigen
Canis familiaris
Adrenergic beta-Antagonists

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