Can bone morphogenetic protein binding peptide increase efficiency of bone formation?

Spine
Scott C McGovernJeffrey C Wang

Abstract

The role of bone morphogenetic protein binding peptide (BBP) in bone formation is reviewed from basic science studies and potential clinical application. We review the discovery and early scientific studies of BBP with emphasis on potential future clinical applications. Biologics delivered locally to enhance bone formation are of increasing importance, particularly in spinal fusion. The most useful agents currently available are bone morphogenetic proteins (BMPs). The indications for recombinant human BMP are expanding; however, certain disadvantages including high costs, unwanted ectopic bone formation, and local inflammatory reaction are becoming more prevalent. As a result, alternate strategies are being developed to provide safer, less expensive, and more efficacious adjuvant agents. This study reviews the existing published data and early experimental results, and explores potential clinical applications of BBP. BBP is a specific binding protein for BMP with an intermediate affinity, which makes it an ideal "slow release" agent. BBP may reduce the time to fusion and more thoroughly control the distribution of bone healing in spinal fusion. Further study is ongoing to explore clinical applications.

References

Mar 1, 1992·The Journal of Bone and Joint Surgery. British Volume·S MiyamotoK Ono
Nov 12, 1965·Science·M R Urist
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M R UristR J DeLange
Nov 20, 2001·The Journal of Bone and Joint Surgery. American Volume·K L Wong, G R Williams
Jun 14, 2002·The Journal of Bone and Joint Surgery. American Volume·Jay R LiebermanThomas A Einhorn
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Keyvan BehnamSamuel S Murray
Dec 29, 2004·Growth Factors·Di ChenGregory R Mundy
Nov 18, 2005·The Spine Journal : Official Journal of the North American Spine Society·Elliot Carlisle, Jeffrey S Fischgrund
Mar 17, 2006·Spine·Rudy ReindlVincent Arlet
Oct 6, 2006·Journal of Spinal Disorders & Techniques·John W McClellanNancy Fullmer
Jan 2, 2007·The Spine Journal : Official Journal of the North American Spine Society·Steven S LuJeffrey C Wang
Feb 27, 2007·The Spine Journal : Official Journal of the North American Spine Society·Brian PerriNeel Anand
Mar 28, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Rahul VaidyaClifford M Les
Apr 7, 2007·Spine·Christoph J SiepeAndreas Korge
May 29, 2007·The Spine Journal : Official Journal of the North American Spine Society·Steven D GlassmanJohn R Dimar
Feb 7, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Chananit SintuuElsa J Brochmann
Apr 12, 2008·Spine·Hyung Soo Ahn, Denis J DiAngelo
Dec 6, 2008·Journal of Spinal Disorders & Techniques·Rahul VaidyaJoseph G Craig
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Kevin S CahillElizabeth B Claus

❮ Previous
Next ❯

Citations

Mar 13, 2014·Journal of Periodontal & Implant Science·Min ZhengXin-Hua Liang
Oct 22, 2010·The Journal of Bone and Joint Surgery. American Volume·Scott A RodeoSuzanne Maher
Sep 5, 2017·Journal of Biomedical Materials Research. Part a·Muzhaozi YuanYi-Xian Qin
Dec 21, 2019·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Saran PairuchvejJatupon Kongtharvonskul
Dec 19, 2015·Spine·Motasem RefaatDominik R Haudenschild
Mar 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dong Nyoung HeoIl Keun Kwon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.