Can Brown Fat Win the Battle Against White Fat?

Journal of Cellular Physiology
Sawsan Elattar, Ande Satyanarayana

Abstract

A rapid growth in the overweight and obese population in the last few decades suggest that the current diet, exercise, awareness or drug strategies are still not effectively restraining the obesity epidemic. Obesity results from increased energy intake, and the body's energy balance shifts towards energy abundance. Therefore, current research is focused on developing new strategies aimed at increasing energy expenditure. As a result, brown adipose tissue (BAT) is receiving tremendous attention since the major function of BAT is to dissipate energy as heat. For example, mouse models that have increased BAT activity or increased numbers of brown-like adipocytes within the white adipose tissue (WAT) are lean and protected from obesity. Alternatively, mouse models that lack BAT activity are more susceptible to age and diet-induced obesity. However, a significant loss of BAT mass during the natural growth process in humans has created enormous challenges in effectively utilizing this tissue to increase energy expenditure. New strategies are primarily focused on expanding the BAT mass and/or activating the existing BAT. In this regard, recent finding that expression of early B cell factor-2 (Ebf2) reprograms the white pre-adipocytes ...Continue Reading

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Sep 4, 2015·Molecular Nutrition & Food Research·Vasso ApostolopoulosBarbora de Courten
Feb 18, 2016·Stem Cells International·Shanshan Hu, Ge Shan
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Jan 4, 2021·Molecular Biology Reports·Jun Ma, Ken Chen
Mar 17, 2021·The Journal of Physiology·Ildiko KaszaC M Alexander

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