Can calcium ionophore "use" in patients with diminished ovarian reserve increase fertilization and pregnancy rates? A randomized, controlled study

Fertility and Sterility
Pinar Caglar AytacHuriye Ayse Parlakgumus

Abstract

To determine whether calcium ionophore solution can improve the fertilization rate in patients with diminished ovarian reserve whose partners have normal sperm parameters. Between January 2014 and August 2014, patients with diminished ovarian reserve were randomized to make artificial oocyte activation with calcium ionophore solution. University hospital. A total of 296 patients who had diminished ovarian reserve and partners with normal sperm parameters were included in the study. Metaphase 2 oocytes were treated with calcium ionophore solution (GM508 Cult-Active) for 15 minutes just after intracytoplasmic sperm injection. Fertilization rate, implantation rate, clinical pregnancy rate, ongoing pregnancy rate. Fertilization, implantation, pregnancy, and ongoing pregnancy rates for the calcium ionophore and control groups were 60.7% and 55.4%, 12.8% and 10.7%, 21% and 12.8%, and 10.9% and 6.1%, respectively. This is the first prospective, randomized, controlled study to analyze the effect of calcium ionophore solution on fertilization rate in patients with diminished ovarian reserve. We did not observe any differences in fertilization, clinical pregnancy, or ongoing pregnancy rates between the groups. We propose that fertilizati...Continue Reading

References

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Citations

Oct 16, 2016·Journal of Assisted Reproduction and Genetics·Konstantinos A EconomouDimitris Loutradis
May 27, 2017·Human Fertility : Journal of the British Fertility Society·Yadava Bapurao JeveTarek Gelbaya
Apr 6, 2018·Systems Biology in Reproductive Medicine·Seda Karabulutİlknur Keskin
Sep 13, 2018·Systems Biology in Reproductive Medicine·George AnifandisDimitrios G Goulis
Feb 24, 2021·Journal of Assisted Reproduction and Genetics·Takashi ShibaharaHiroyuki Minoura
Aug 13, 2021·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Kevin K W LamWilliam S B Yeung

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