Can clinical data predict progression to dementia in amnestic mild cognitive impairment?

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
Lesley FellowsHoward Chertkow

Abstract

To determine whether clinical data obtained by history and physical examination can predict eventual progression to dementia in a cohort of elderly people with mild cognitive impairment. A prospective, longitudinal study of a cohort of elderly subjects with amnestic Mild Cognitive Impairment (MCI). Ninety subjects meeting the criteria for amnestic MCI were recruited and followed annually for an average of 3.3 years. Main outcome measure was the development of dementia determined by clinical assessment with confirmatory neuropsychological evaluation. Fifty patients (56%) developed dementia on follow-up. They were older, had lower Mini-mental status exam (MMSE) scores and a shorter duration of symptoms at the time of first assessment. Multivariate logistic regression analysis identified age at symptom onset as the only clinical parameter which distinguished the group that deteriorated to dementia from the group that did not. The odds ratio for age was 1.1 (confidence interval 1.04 - 1.18). Patients presenting with amnestic MCI insufficient for the diagnosis of dementia are at high risk of developing dementia on follow-up. In our cohort, 56% were diagnosed with dementia over an average period of 5.9 years from symptom onset. The o...Continue Reading

References

Sep 1, 1975·Archives of Neurology·V C HachinskiL Symon
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 1, 1991·Neurology·C FlickerB Reisberg
Nov 1, 1990·Archives of Neurology·J McGloneD R Evans
Apr 1, 1989·Archives of Neurology·E H RubinT Vendegna
Apr 1, 1989·Archives of Neurology·M Storandt, R D Hill
Aug 1, 1987·Journal of Clinical and Experimental Neuropsychology·G J Larrabee
Sep 1, 1987·Archives of Neurology·F J HuffS Belle
Dec 1, 1987·Journal of Consulting and Clinical Psychology·M Mitchell
Feb 1, 1985·Neurology·J A MortimerL M Schuman
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Aug 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·C BrayneE S Paykel
Apr 26, 1995·JAMA : the Journal of the American Medical Association·R C PetersenL T Kurland
Apr 1, 1994·Archives of General Psychiatry·E S PaykelD O'Connor
Sep 1, 1993·Academic Medicine : Journal of the Association of American Medical Colleges·R Dresser
Dec 1, 1995·The American Journal of Psychiatry·G W SmallM A Mandelkern
Jan 1, 1996·Journal of the American Geriatrics Society·C JonkerJ Lindeboom
Jan 1, 1996·Neurology·B SchmandJ Lindeboom
Apr 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·K RitchieJ Touchon
Jul 1, 1996·Age and Ageing·S T O'KeeffeM Lye
Jan 1, 1996·Alzheimer Disease and Associated Disorders·L J Thal
Mar 1, 1997·Journal of the American Geriatrics Society·D P DevanandY Stern
Jun 1, 1997·Archives of Neurology·P W SchofieldY Stern
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
May 18, 2000·Archives of Neurology·R C Petersen
Mar 20, 2001·Archives of Neurology·J C MorrisL Berg
Mar 20, 2001·Archives of Neurology·D LaurinK Rockwood
May 8, 2002·Journal of Neurology·Pieter Jelle VisserJellemer Jolles
Aug 2, 2002·Current Opinion in Neurology·Howard Chertkow
Sep 3, 2002·Annals of Neurology·Jan Cees De GrootMonique M B Breteler
Dec 25, 2002·Neurology·M J EngelhartM M B Breteler
May 21, 2003·Archives of Neurology·Robert C GreenLindsay Farrer
Jun 11, 2003·Neurology·L L BarnesD A Bennett

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Citations

Aug 21, 2013·Developmental Disabilities Research Reviews·Sharon J Krinsky-McHale, Wayne Silverman
Mar 27, 2015·Journal of Neuropsychology·Sara García-HerranzHerminia Peraita
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Simon CloutierSylvie Belleville
Feb 11, 2009·American Journal of Alzheimer's Disease and Other Dementias·D V MorettiG B Frisoni
Feb 25, 2011·Dementia and Geriatric Cognitive Disorders·Haiqun XieLisa Koski
Oct 9, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Cynthia H Y Fu, Sergi G Costafreda
Dec 19, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Josef FinstererCarla A Scorza

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