Can concurrent core biopsy and fine needle aspiration biopsy improve the false negative rate of sonographically detectable breast lesions?

BMC Cancer
Yao-Lung Kuo, Tsai-Wang Chang

Abstract

The aims of this study were to determine the accuracy of concurrent core needle biopsy (CNB) and fine needle aspiration biopsy (FNAB) for breast lesions and to estimate the false-negative rate using the two methods combined. Over a seven-year period, 2053 patients with sonographically detectable breast lesions underwent concurrent ultrasound-guided CNB and FNAB. The sonographic and histopathological findings were classified into four categories: benign, indeterminate, suspicious, and malignant. The histopathological findings were compared with the definitive excision pathology results. Patients with benign core biopsies underwent a detailed review to determine the false-negative rate. The correlations between the ultrasonography, FNAB, and CNB were determined. Eight hundred eighty patients were diagnosed with malignant disease, and of these, 23 (2.5%) diagnoses were found to be false-negative after core biopsy. After an intensive review of discordant FNAB results, the final false-negative rate was reduced to 1.1% (p-value = 0.025). The kappa coefficients for correlations between methods were 0.304 (p-value < 0.0001) for ultrasound and FNAB, 0.254 (p-value < 0.0001) for ultrasound and CNB, and 0.726 (p-value < 0.0001) for FNAB a...Continue Reading

References

Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·A HitchcockI O Ellis
Jul 1, 1989·Journal of Clinical Pathology·J Lamb, T J Anderson
Mar 1, 1994·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·T J RissanenI I Suramo
Apr 1, 1994·AJR. American Journal of Roentgenology·J J GisvoldS H Jung
May 1, 1993·Radiology·S H ParkerD G Clark
Sep 1, 1997·Radiology·R J Jackman, F A Marzoni
Sep 2, 1998·Radiology·L LibermanA F Abramson
Feb 4, 1999·AJR. American Journal of Roentgenology·L LibermanP P Rosen
Jan 3, 2001·Cancer·L LibermanD D Dershaw
Jan 10, 2001·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·D N SmithR L Christian
Sep 11, 2001·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·J M Schoonjans, R F Brem
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Helena M Verkooijen, UNKNOWN Core Biopsy After Radiological Localisation (COBRA) Study Group
Nov 7, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Martha B MainieroBarbara Schepps
Dec 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T AgarwalD J Hadjiminas
Jun 24, 2003·AJR. American Journal of Roentgenology·Pavel CrystalMichael J Koretz
Nov 8, 2003·Surgery·Joseph P CroweKatherine B Lee
Dec 4, 2003·Diagnostic Cytopathology·Aasmund BernerBjørn Risberg
Dec 3, 2004·Environmental Science & Technology·Laurent DambiesSpiro D Alexandratos
Feb 3, 2005·Breast Disease·C S HuangC Y Shen
Oct 12, 2005·The Breast : Official Journal of the European Society of Mastology·S Pilgrim, D Ravichandran
Nov 16, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shin UsamiNoriaki Ohuchi
Jan 21, 2006·Radiology·Cecilia L MercadoJoan Cangiarella

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Citations

Jan 1, 2010·BMJ Case Reports·Annabel M RuiterPrabath W B Nanayakkara
Jun 22, 2012·International Archives of Medicine·Guerino Barbalaco NetoLuiz Carlos de Abreu
Jul 5, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Lynn M BekrisJames B Leverenz

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