Can corneal pannus with trachomatous inflammation--follicular be used in combination as an improved specific clinical sign for current ocular Chlamydia trachomatis infection?

Parasites & Vectors
Tamsyn DerrickAnna R Last

Abstract

Trachoma is a blinding disease caused by conjunctival infection with Chlamydia trachomatis (Ct). Mass drug administration (MDA) for trachoma control is administered based on the population prevalence of the clinical sign of trachomatis inflammation - follicular (TF). However, the prevalence of TF is often much higher than the prevalence of Ct infection. The addition of a clinical sign specific for current ocular Ct infection to TF could save resources by preventing unnecessary additional rounds of MDA. Study participants were aged between 1-9 years and resided on 7 islands of the Bijagos Archipelago, Guinea Bissau. Clinical grades for trachoma and corneal pannus and ocular swab samples were taken from 80 children with TF and from 81 matched controls without clinical evidence of trachoma. Ct infection testing was performed using droplet digital PCR. New pannus was significantly associated with Ct infection after adjustment for TF (P = 0.009, OR = 3.65 (1.4-9.8)). Amongst individuals with TF, individuals with new pannus had significantly more Ct infection than individuals with none or old pannus (75.0% vs 45.5%, Chi(2) P = 0.01). TF and new pannus together provide a highly specific (91.7%), but a poorly sensitive (51.9%) clinical...Continue Reading

References

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Citations

Oct 27, 2016·PLoS Neglected Tropical Diseases·Athumani M RamadhaniMatthew J Burton
Jan 15, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ramandeep Singh SahotaEmma M Harding-Esch
Aug 11, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert ButcherAnthony W Solomon

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Methods Mentioned

BETA
MDA
PCR

Software Mentioned

Quantalife
R

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