Oct 1, 2016

Can CuO nanoparticles lead to epigenetic regulation of antioxidant enzyme system?

Journal of Applied Toxicology : JAT
Sandesh Chibber, Rishi Shanker

Abstract

Copper has been used from ancient time in various applications. Scientists have exploited its means of exposure and consequences to living organisms. The peculiar property of nanomaterials that is a high surface to volume ratio has increased the range of application in products. Copper oxide nanoparticles (CuO NPs) are widely used in industrial applications such as semiconductor devices, gas sensor, batteries, solar energy converter, microelectronics, heat transfer fluids and consumer products. In contrast, acute toxicity of CuO NPs has also been reported. Subsequently, human and environmental health may be at a high risk. Their frequent use can also contaminate ecosystems. Therefore, the toxicity of CuO NPs needs to be thoroughly understood. In this review, we have tried to discuss the recent facts and mechanism that have been explored for CuO NPs-induced toxicity at a cellular, in vivo and ecotoxicological level. Accordingly, the main cause for induction of toxicity by CuO NPs is the generation of reactive oxygen species (ROS) followed by the mitochondrial destruction that leads to apoptosis via the intrinsic pathway or under the condition such as hypoxia cell on exposure to CuO NPs may commit to necrosis. Moreover, CuO NPs a...Continue Reading

Mentioned in this Paper

JUN gene
Copper dioxide (CuO2)
JUND gene
In Vivo
Biochemical Pathway
Necrosis
Genes
Mitogen-Activated Protein Kinases
Antioxidant Effect
Antioxidants

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