Can cyclosporin A induce permanent remission of atopic dermatitis?

The British Journal of Dermatology
N Sepp, P O Fritsch

Abstract

Three adult patients, who had suffered from severe therapy-resistant atopic dermatitis since childhood, were treated with long-term (29, 44 and 22 months) low-dose (maintenance dose: 0.5-0.7 mg/kg) cyclosporin A (CyA). All responded rapidly within 3-5 weeks and exhibited only minor exacerbations during the first phases of therapy. No relapse occurred in any of the patients after drug withdrawal. All patients remained symptom-free, except for occasional very mild and easily manageable localized lesions, for follow-up periods of 34, 13 and 22 months. Side-effects were minimal or tolerable (mild hypertrichosis in two patients, a slight decrease of creatinine clearance in one). In contrast with the clinical improvement, all atopy-related parameters such as blood eosinophilia, elevated IgE levels and specific IgE (RAST) reactivity remained essentially unchanged, as were skin dryness and stigmata of atopy. It is concluded that long-term low-dose CyA treatment may lead to permanent or long-term total or subtotal remission of atopic dermatitis.

References

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Citations

May 28, 1994·Lancet·B PrzybillaF Ruëff
Dec 12, 2001·International Journal of Dermatology·G L CapellaA F Finzi
Jan 1, 1997·The British Journal of Dermatology·J Berth-JonesB R Allen
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Apr 22, 2005·Veterinary Dermatology·Stacey N Radowicz, Helen T Power
Jun 1, 1996·Journal of the American Academy of Dermatology·J Berth-JonesR A Graham-Brown
Jul 26, 2014·Pediatric Dermatology·Cathryn SibbaldMiriam Weinstein
Nov 30, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·A Hernández-MartínC de Lucas-Collantes
Jul 1, 1996·Journal of the American Academy of Dermatology·M J Rothe, J M Grant-Kels
Jun 1, 1997·Journal of the American Academy of Dermatology·R BrehlerT A Luger
Nov 26, 2010·Journal of the American Academy of Dermatology·Karrie T AmorAlan Menter

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