Can cystatin C become an easy and reliable tool for anesthesiologists to calculate glomerular filtration rate?

Journal of Anaesthesiology, Clinical Pharmacology
Navpreet Kaur AulakhMirley Rupinder Singh

Abstract

The aim was to evaluate the role of cystatin C as a noninvasive and easy marker of glomerular filtration rate (GFR) estimation in voluntary kidney donors. We retrospectively evaluated 40 voluntary kidney donors. They underwent complete biochemical and nuclear tests as a part of transplant workup. Serum cystatin C, serum creatinine, and Tc-99m diethylene-triamine-penta-acetic acid (DTPA) were used in our study. We calculated GFR using the chronic kidney disease epidemiology collaboration (CKD-EPI) formula based on creatinine only (GFR-CKD-EPI-creat), CKD-EPI formula using creatinine and cystatin C (GFR-CKD-EPI-cyst-creat), and modification of diet in renal disease (MDRD) and CKD-EPI cystatin C equation (2012) (GFR-cyst). Data was evaluated using the SPSS software (version 11.5). The correlation analysis and analysis of variance was used for statistical computation. Agreement was determined using analyze-it version 2.30 for MS-Excel 12+. The mean age of the donors in our study was 49.83 ± 13.06. The mean cystatin C in females was 0.72 ± 0.12, the mean cystain C in males was 0.87 ± 0.23. On correlating GFR-cyst with GFR-DTPA the Pearson correlation coefficient (ρ) was found to be 0.388 this correlation was significant with P < 0.0...Continue Reading

References

Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E CollA Darnell
Jul 31, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vikas R DharnidharkaGary Stevens
Dec 21, 2004·Clinical Biochemistry·Guido FillerAnders Grubb
Mar 16, 2007·American Journal of Nephrology·Ahmed ZahranAhmed Shoker
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Feb 9, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Krishnaswamy JaisureshApoorva Jain
Jul 6, 2012·The New England Journal of Medicine·Lesley A InkerUNKNOWN CKD-EPI Investigators
Nov 9, 2012·Korean journal of urology·Hyun Ho HanWoong Kyu Han

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Citations

Nov 30, 2018·Journal of Applied Physiology·Guillaume SpielmannJohn Campbell

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Methods Mentioned

BETA
urine collection

Software Mentioned

Excel
Analyze
it
MS

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