Can cytological features differentiate reactive renal tubular cells from low-grade urothelial carcinoma cells?

Cytopathology : Official Journal of the British Society for Clinical Cytology
H OhsakiR Haba

Abstract

To compare the cytomorphological and immunocytochemical features of reactive renal tubular cells and low-grade urothelial carcinoma cells (LG-UCs). We examined 15 cytological parameters in 38 cases with reactive renal tubular cells in renal disease and 20 cases of LG-UCs from bladder cancer that had been diagnosed by histological examination. Voided urine cytological parameters evaluated were as follows: (i) maximum cell numbers of clusters, (ii) cannibalism, (iii) rosette-like arrangement, (iv) hobnail-shaped cells, (v) vacuolated cytoplasm, (vi) intracytoplasmic haemosiderin, (vii) irregular nuclear contours, (viii) chromatin pattern, (ix) prominent nucleoli, (x) cast encasement, (xi) casts, (xii) dysmorphic erythrocytes, (xiii) isomorphic erythrocytes, (xiv) necrosis, and (xv) vimentin reactivity. The above parameters were determined using Mann-Whitney U-test and chi-square test, with differences considered significant at P  <  0.05. In reactive renal tubular cells, low to moderate cell numbers of clusters (fewer than 50 cells), rosette-like arrangement, hobnail-shaped cells, vacuolated cytoplasm, intracytoplasmic haemosiderin, euchromatin pattern, prominent nucleoli, dysmorphic erythrocytes and vimentin reactivity were pres...Continue Reading

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Citations

Sep 13, 2013·Der Urologe. Ausg. A·M BöhmUNKNOWN Arbeitskreis Urinzytologie der DGU (Deutsche Gesellschaft für Urologie)
Oct 10, 2013·International Journal of Clinical Oncology·Satoru MutoShigeo Horie
Jun 29, 2011·Diagnostic Cytopathology·S A Thiryayi, D N Rana
Nov 27, 2016·Diagnostic Cytopathology·Margareta Strojan FležarHelena Gutnik
Jan 29, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·H OhsakiR Haba
Nov 14, 2018·Nature Reviews. Cancer·Stefano Fais, Michael Overholtzer

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